• Name

  N,N-BIS(2-HYDROXYPROPYL)ANILINE

• EINECS 221-360-7
• CAS No. 3077-13-2
• Article Data10
• CAS DataBase
• Density 1.106 g/cm³
• Solubility
• Melting Point
• Formula C₁₂H₁₉NO₂
• Boiling Point 358.5 °C at 760 mmHg
• Molecular Weight 209.288
• Flash Point 180.2 °C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 2-Propanol,1,1'-(phenylimino)di- (7CI,8CI);Isonol 100;Isonol C 100;Isonol N 100;N,N-Bis(2-hydroxypropyl)aniline;N,N-Di(2-hydroxypropyl)aniline;NSC 166506;
• PSA 43.70000
• LogP 1.25460

Synthetic route

62-53-3

aniline

75-56-9, 16033-71-9

methyloxirane

A

3233-06-5

1-anilino-propan-2-ol

B

3077-13-2

N-phenyl-bis-(2-hydroxypropyl)amine

Conditions

Conditions	Yield
With zinc(II) bis(tetrafluoroborate) hydrate at 20℃; for 0.333333h; Inert atmosphere; Neat (no solvent);	A 97% B n/a
With ferrocenium(III) tetrafluoroborate In neat (no solvent) at 0 - 25℃; for 7h; regioselective reaction;	A 74% B 19%
With water at 100℃;

...Expand

996-21-4

1-iodopropan-2-ol

62-53-3

aniline

A

3233-06-5

1-anilino-propan-2-ol

B

3077-13-2

N-phenyl-bis-(2-hydroxypropyl)amine

Conditions

Conditions	Yield
With triethylamine In methanol for 4h; Reflux;	A 60% B 2.5%

...Expand

62-53-3

aniline

75-56-9, 16033-71-9

methyloxirane

3077-13-2

N-phenyl-bis-(2-hydroxypropyl)amine

Conditions

Conditions	Yield
With 1,4-dioxane at 170℃;

17639-93-9

2-chloro-propionic acid methyl ester

62-53-3

aniline

3077-13-2

N-phenyl-bis-(2-hydroxypropyl)amine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride Multistep reaction;

108-32-7

1,2-propylene cyclic carbonate

62-53-3

aniline

A

109605-09-6

2,6-dimethyl-4-phenylmorpholine

B

16955-09-2

2-anilino-1-propanol

C

3233-06-5

1-anilino-propan-2-ol

D

1258887-18-1

2,5-dimethyl-4-phenylmorpholine

E

3077-13-2

N-phenyl-bis-(2-hydroxypropyl)amine

F

129118-34-9

N-(2-hydroxypropyl)-N-(2-hydroxy-1-methylethyl)aniline

Conditions

Conditions	Yield
With tri-n-octyl(methyl)phosphonium bromide at 170℃; for 40h; Ionic liquid; Neat (no solvent);

...Expand

3077-13-2

N-phenyl-bis-(2-hydroxypropyl)amine

144967-39-5

diisopropoxydivinylsilane

144967-47-5

2,2-divinyl-4,8-dimethyl-6-phenyl-1,3-dioxa-6-aza-2-silacyclooctane

Conditions

Conditions	Yield
With sodium methylate In 1,4-dioxane; methanol Heating;	50%

3077-13-2

N-phenyl-bis-(2-hydroxypropyl)amine

67-64-1

acetone

2,2,4,8-Tetramethyl-6-phenyl-[1,3,6]dioxazocane

Conditions

Conditions	Yield
With 3 A molecular sieve In dichloromethane Ambient temperature;	42%

75-44-5

phosgene

3077-13-2

N-phenyl-bis-(2-hydroxypropyl)amine

A

93371-13-2

4,8-Dimethyl-6-phenyl-5,6,7,8-tetrahydro-4H-1,3,6-dioxazocin-2-one

93371-13-2, 93371-14-3

4,8-Dimethyl-6-phenyl-5,6,7,8-tetrahydro-4H-1,3,6-dioxazocin-2-one

Conditions

Conditions	Yield
With pyridine In ethyl acetate	A 19% B 26%

...Expand

50-00-0

formaldehyd

3077-13-2

N-phenyl-bis-(2-hydroxypropyl)amine

13364-26-6

bis-{4-[bis-(2-hydroxy-propyl)-amino]-phenyl}-methane

Conditions

Conditions	Yield
With hydrogenchloride; ethanol

3077-13-2

N-phenyl-bis-(2-hydroxypropyl)amine

109605-09-6

2,6-dimethyl-4-phenylmorpholine

Conditions

Conditions	Yield
With sulfuric acid at 160℃;

3077-13-2

N-phenyl-bis-(2-hydroxypropyl)amine

101741-62-2

2,6-dimethyl-4-[4-(4-nitro-phenylazo)-phenyl]-morpholine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: H2SO4 / 160 °C View Scheme

N,N-Bis(2-hydroxypropyl)aniline Specification