N,N-Dimethylethanolamine

The CAS registry number of N,N-Dimethylethanolamine is 108-01-0. Its EINECS registry number is 203-542-8. The IUPAC name is 2-(dimethylamino)ethanol. In addition, the molecular formula is C₄H₁₁NO. What's more, it is an antidepressive agent that has also been used in the treatment of movement disorders. It can be used as a raw material for resin, medicine, dyes and paint solvents. And it is used as a intermediate in the manufacture of dyes, fiber treating agent, medicine and anticorrosive additives.

Physical properties about N,N-Dimethylethanolamine are: (1)ACD/LogP: -0.328; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.19; (4)ACD/LogD (pH 7.4): -1.68; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 3; (12)Index of Refraction: 1.433 ; (13)Molar Refractivity: 25.837 cm³; (14)Molar Volume: 99.322 cm³; (15)Polarizability: 10.242 10-24cm³; (16)Surface Tension: 30.6580009460449 dyne/cm; (17)Density: 0.897 g/cm³; (18)Flash Point: 40.556 °C; (19)Enthalpy of Vaporization: 43.395 kJ/mol; (20)Boiling Point: 134.999 °C at 760 mmHg; (21)Vapour Pressure: 3.39299988746643 mmHg at 25°C

Preparation of N,N-Dimethylethanolamine: it can be prepared by dimethylamine and epoxyethane through ammoniation reaction. And then after a series of distillation, rectification and dehydration you can get the desired product.

Uses of N,N-Dimethylethanolamine: it can react with (2-chloro-ethyl)-dimethyl-amine to get bis-(2-dimethylamino-ethyl)-ether. This reaction will need reagent 50 percent NaOH, catalyst Adogen 464 and solvent tetrahydrofuran. The reaction time is 6 hours by heating. The yield is about 35%.

When you are using this chemical, please be cautious about it as the following:
This chemical is flammable and can cause burns. And it is harmful by inhalation, in contact with skin and if swallowed. When you are using it, wear suitable protective clothing, gloves and eye/face protection and avoid contact with eyes. In case of contact with eyes, rinse immediately with plenty of water or soap-suds and seek medical advice. And in case of accident or if you feel unwell, seek medical advice immediately (show label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: CN(C)CCO
(2)InChI: InChI=1/C4H11NO/c1-5(2)3-4-6/h6H,3-4H2,1-2H3
(3)InChIKey: UEEJHVSXFDXPFK-UHFFFAOYAY

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LDLo	intraperitoneal	450mg/kg (450mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 85, Pg. 642, 1954.
mouse	LC50	inhalation	3250mg/m3 (3250mg/m3)	SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 14(11), Pg. 52, 1970.
mouse	LD50	intraperitoneal	234mg/kg (234mg/kg)	BEHAVIORAL: ATAXIA	Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 249, 1948.
mouse	LD50	subcutaneous	961mg/kg (961mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: TREMOR BEHAVIORAL: COMA	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 225, Pg. 428, 1955.
rabbit	LD50	skin	1370uL/kg (1.37mL/kg)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
rat	LC50	inhalation	1641ppm/4H (1641ppm)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Fundamental and Applied Toxicology. Vol. 9, Pg. 512, 1987.
rat	LD50	intraperitoneal	1080mg/kg (1080mg/kg)		Toxicology and Applied Pharmacology. Vol. 12, Pg. 486, 1968.
rat	LD50	oral	2gm/kg (2000mg/kg)		Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. Vol. 20, Pg. 393, 1974.