Product Name

  • Name

    Acephate

  • EINECS 250-241-2
  • CAS No. 30560-19-1
  • Article Data17
  • CAS DataBase
  • Density 1.263 g/cm3
  • Solubility Soluble in water
  • Melting Point 93 °C
  • Formula C4H10NO3PS
  • Boiling Point 2 °C
  • Molecular Weight 183.168
  • Flash Point 2°C
  • Transport Information UN1648 3/PG 2
  • Appearance White solid
  • Safety 2-36-36/37-16
  • Risk Codes 22-36-20/21/22-11
  • Molecular Structure Molecular Structure of 30560-19-1 (Acephate)
  • Hazard Symbols HarmfulXn, FlammableF
  • Synonyms 75 SP;Ortran;Acephat [German];Phosphoramidothioic acid, acetyl-, O,S-dimethyl ester;Ortril;Acetamidophos;Acephate [ANSI:BSI:ISO];Chevron RE 12,420;Phosphoramidothioic acid,acetyl-,O,S-dimethyl ester;Chevron Orthene;Acephate, technical;EPA Pesticide Chemical Code 103301;O,S-Dimethylacetylphosphoroamidothioate;ENT 27822;N-(methoxy-methylsulfanyl-phosphoryl)acetamide;
  • PSA 90.51000
  • LogP 1.63090

Synthetic route

acetamide
60-35-5

acetamide

phosphorochloridothioic acid,O,S-dimethyl ester
3711-50-0

phosphorochloridothioic acid,O,S-dimethyl ester

Acephate
30560-19-1

Acephate

Conditions
ConditionsYield
With triethylamine In toluene at 5 - 30℃; for 5h; Reagent/catalyst; Temperature; Concentration;84%
With hydrogenchloride In water for 14h; Reflux;102 g
acetamide
60-35-5

acetamide

dimethyl chlorothiophosphate
2524-03-0

dimethyl chlorothiophosphate

Acephate
30560-19-1

Acephate

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran at 60℃;63%
calcium salt of O,S-dimethyl-N-acetylphosphoroamidothioate

calcium salt of O,S-dimethyl-N-acetylphosphoroamidothioate

Acephate
30560-19-1

Acephate

Mio
10265-92-6

Mio

acetic anhydride
108-24-7

acetic anhydride

Acephate
30560-19-1

Acephate

Conditions
ConditionsYield
With sulfuric acid Heating;
With sulfuric acid In dichloromethane at 60 - 70℃; for 2.5h; Large scale;
With sulfuric acid at 35 - 45℃; for 2.5h; Large scale;4826 kg
O,O-dimethyl N-acetylphosphoramidothioate
42072-27-5

O,O-dimethyl N-acetylphosphoramidothioate

dimethyl sulfate
77-78-1

dimethyl sulfate

Acephate
30560-19-1

Acephate

Conditions
ConditionsYield
In dichloromethane Heating;
Acephate
30560-19-1

Acephate

C3H7NO3PS(1-)*Na(1+)

C3H7NO3PS(1-)*Na(1+)

Conditions
ConditionsYield
With sodium iodide In acetone for 4h; Heating;100%
ethanol
64-17-5

ethanol

Acephate
30560-19-1

Acephate

A

methanesulfonic acid
75-75-2

methanesulfonic acid

B

Acetyl-phosphoramidic acid ethyl ester methyl ester

Acetyl-phosphoramidic acid ethyl ester methyl ester

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid
...Expand
Acephate
30560-19-1

Acephate

demethylthioacephate
82452-61-7

demethylthioacephate

Conditions
ConditionsYield
With water; triethylamine; 3-chloro-benzenecarboperoxoic acid
With 3,3-dimethyldioxirane In water-d2; acetone for 24h;
Acephate
30560-19-1

Acephate

iso-butanol
78-92-2, 15892-23-6

iso-butanol

A

methanesulfonic acid
75-75-2

methanesulfonic acid

B

sec-butyl methanesulfonate
16156-54-0

sec-butyl methanesulfonate

C

demethylthioacephate
82452-61-7

demethylthioacephate

D

Acetyl-phosphoramidic acid sec-butyl ester methyl ester

Acetyl-phosphoramidic acid sec-butyl ester methyl ester

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acidA n/a
B n/a
C 52 % Spectr.
D 48 % Spectr.
...Expand
Acephate
30560-19-1

Acephate

Barium Salt of O,S-Dimethyl-N-Acetylphosphoroamidothioate

Barium Salt of O,S-Dimethyl-N-Acetylphosphoroamidothioate

Conditions
ConditionsYield
With barium dihydroxide In dichloromethane
Acephate
30560-19-1

Acephate

Sodium Salt of O,S-Dimethyl-N-acetylphosphoroamidothioate

Sodium Salt of O,S-Dimethyl-N-acetylphosphoroamidothioate

Conditions
ConditionsYield
With sodium carbonate In methanol
Acephate
30560-19-1

Acephate

calcium salt of O,S-dimethyl-N-acetylphosphoroamidothioate

calcium salt of O,S-dimethyl-N-acetylphosphoroamidothioate

Conditions
ConditionsYield
With calcium hydroxide In methanol
Acephate
30560-19-1

Acephate

tin(IV) chloride
7646-78-8

tin(IV) chloride

N-(O,S-dimethylphosphoryl)acetamide stannic chloride complex
183606-67-9

N-(O,S-dimethylphosphoryl)acetamide stannic chloride complex

Conditions
ConditionsYield
solvent: CH2Cl2 or pentane; Sn-compd. addn. (dropwise) to soln. of ligand; ppt. filtration off, washing with solvent; elem. anal.;
Acephate
30560-19-1

Acephate

phosphoramidic acid monomethyl ester
19255-94-8

phosphoramidic acid monomethyl ester

Conditions
ConditionsYield
With 10 wt% La2O3/Bi2O3 doped silver orthophosphate for 2h; Kinetics; Photolysis;

Orthene Specification

 The Orthene, with the CAS registry number 30560-19-1,is also known as O,S-Dimethyl acetylphosphoramidothioate; N-Acetyl-phosphoramidothioic acid O,S-dimethyl ester. It belongs to the product categories of Insecticides;Organophorous;Pesticides&Metabolites. This chemical's molecular formula is C4H10NO3PS and molecular weight is 183.16.Its EINECS number is 250-241-2. What's more,Its systematic name is Acephate. It is a White Solid which is used as insecticide.Acephate is sold as a soluble powder, as pressurized aerosol, as emulsifiable concentrates, and in tree injection systems and granular formulations.The Orthene is harmful by inhalation, in contact with skin and if swallowed  and irritating to the eyes.It need keep out of the reach of children .When you use it ,wear suitable protective clothing and gloves and keep away from sources of ignition - No smoking.

Physical properties about L-Lysine Orthene are:
(1)ACD/LogP:  -0.85; (2)# of Rule of 5 Violations:  0; (3)ACD/LogD (pH 5.5):  -0.85; (4)ACD/LogD (pH 7.4):  -0.85; (5)ACD/BCF (pH 5.5):  1.00; (6)ACD/BCF (pH 7.4):  1.00; (7)ACD/KOC (pH 5.5):  8.22; (8)ACD/KOC (pH 7.4):  8.21; (9)#H bond acceptors:  4; (10)#H bond donors:  1; (11)#Freely Rotating Bonds:  2; (12)Index of Refraction:  1.475; (13)Molar Refractivity:  40.821 cm3; (14)Molar Volume:  144.977 cm3; (15)Surface Tension:  40.9529991149902 dyne/cm; (16)Density:  1.263 g/cm3.

You can still convert the following datas into molecular structure:
(1)SMILES:O=C(NP(=O)(OC)SC)C;
(2)Std. InChI:InChI=1S/C4H10NO3PS/c1-4(6)5-9(7,8-2)10-3/h1-3H3,(H,5,6,7);
(3)Std. InChIKey:YASYVMFAVPKPKE-UHFFFAOYSA-N.

The toxicity data of Orthene are as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - domestic LD50 oral 106mg/kg (106mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Archives of Environmental Contamination and Toxicology. Vol. 10, Pg. 185, 1981.
bird - wild LD50 oral 140mg/kg (140mg/kg)   Pesticide Manual. Vol. 9, Pg. 4, 1991.
chicken LD50 oral 800mg/kg (800mg/kg)   Neurotoxicology. Vol. 11, Pg. 483, 1990.
chicken LD50 unreported 568mg/kg (568mg/kg)   Defense des Vegetaux. Vol. 28, Pg. 231, 1974.
dog LDLo oral 681mg/kg (681mg/kg)   Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 1, 1973.
duck LD50 oral 350mg/kg (350mg/kg)   "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969Vol. 5, Pg. 4, 1976.
mammal (species unspecified) LD50 oral 321mg/kg (321mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 13, Pg. 483, 1984.
mouse LCLo inhalation 2200mg/m3/5H (2200mg/m3)   Toxicology and Applied Pharmacology. Vol. 45, Pg. 232, 1978.
mouse LD50 oral 233mg/kg (233mg/kg)   Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. Vol. 14, Pg. 226, 1980.
rabbit LD50 skin 2gm/kg (2000mg/kg)   "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976.
rat LD50 oral 700mg/kg (700mg/kg)   United States Patent Document. Vol. #3716600,
rat LD50 skin > 2500mg/kg (2500mg/kg)   Fundamental and Applied Toxicology. Vol. 7, Pg. 299, 1986.

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