Oxirane,2-[[4-(2-methoxyethyl)phenoxy]methyl]- supplier

Name
[[p-(2-methoxyethyl)phenoxy]methyl]oxirane
EINECS 260-353-3
CAS No. 56718-70-8
Article Data26
CAS DataBase
Density 1.099 g/cm³
Solubility
Melting Point 67-68℃ (ligroine )
Formula C₁₂H₁₆O₃
Boiling Point 300.6 °C at 760 mmHg
Molecular Weight 208.257
Flash Point 100.1 °C
Transport Information
Appearance Pale-yellow oil
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Oxirane,[[4-(2-methoxyethyl)phenoxy]methyl]- (9CI);MEEPB;2-{[4-(2-Methoxyethyl)phenoxy]methyl}oxirane;((p-(2-Methoxyethyl)phenoxy)methyl)oxirane;[[4-(2-Methoxyethyl)phenoxy]methyl]-oxirane;
PSA 30.99000
LogP 1.65310

Synthetic route

: 56718-71-9
4-(2-methoxyethyl)phenol

: 106-89-8
epichlorohydrin

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

Conditions

Conditions	Yield
With sodium hydroxide at 85 - 90℃; pH=8; Temperature; pH-value; Flow reactor;	95.2%
With sodium hydroxide at 90 - 115℃; under 1500.15 - 2250.23 Torr; pH=9; Flow reactor;	95.2%
With sodium hydroxide In water at 40 - 45℃; for 3 - 5h;	93%

: 56718-71-9
4-(2-methoxyethyl)phenol

: 106-89-8
epichlorohydrin

A: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

B: 56718-76-4
(+/-)-1-[4-(2-methoxyethyl)phenoxy]-3-chloro-2-propanol

Conditions

Conditions	Yield
With sodium hydroxide	A 90% B 10%
Stage #1: 4-(2-methoxyethyl)phenol With potassium hydroxide In methanol at 40 - 45℃; for 1h; Stage #2: epichlorohydrin at 40℃; for 24h;
With sodium hydroxide In water at 30 - 40℃; for 5h; Temperature;

...Expand

: 74254-83-4
Toluene-4-sulfonic acid 2-hydroxy-3-[4-(2-methoxy-ethyl)-phenoxy]-propyl ester

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

Conditions

Conditions	Yield
With sodium methylate In methanol at 50 - 60℃; for 0.5h;	0.50 g

: 56718-71-9
4-(2-methoxyethyl)phenol

: 3132-64-7
1,2-Epoxy-3-bromopropane

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

Conditions

Conditions	Yield
With base

: 2491-38-5
2-bromo-1-(4'-hydroxyphenyl)-1-ethanone

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: methanol 2: H2; AcOH / Pd/C 3: 90 percent / aq. NaOH View Scheme

: 32136-81-5
alpha-methoxy-4-hydroxyacetophenone

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: H2; AcOH / Pd/C 2: 90 percent / aq. NaOH View Scheme
Multi-step reaction with 5 steps 1: 96 percent / H2 / 10percent Pd/C / ethanol / 4 h / 2327.2 Torr 2: 85 percent / K2CO3 / acetone / 7 h / Heating 3: 80 percent / OsO4, N-methylmorpholine-N-oxide / H2O; acetone / 15 h 4: pyridine / 24 h / Ambient temperature 5: 0.50 g / NaOCH3 / methanol / 0.5 h / 50 - 60 °C View Scheme

: 99-93-4
4-Hydroxyacetophenone

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: CuBr2 / ethyl acetate 2: methanol 3: H2; AcOH / Pd/C 4: 90 percent / aq. NaOH View Scheme

: 6305-04-0
p-hydroxyphenacyl chloride

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 90 percent / methanol / 24 h / Ambient temperature 2: 96 percent / H2 / 10percent Pd/C / ethanol / 4 h / 2327.2 Torr 3: 85 percent / K2CO3 / acetone / 7 h / Heating 4: 80 percent / OsO4, N-methylmorpholine-N-oxide / H2O; acetone / 15 h 5: pyridine / 24 h / Ambient temperature 6: 0.50 g / NaOCH3 / methanol / 0.5 h / 50 - 60 °C View Scheme

: 56718-71-9
4-(2-methoxyethyl)phenol

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 85 percent / K2CO3 / acetone / 7 h / Heating 2: 80 percent / OsO4, N-methylmorpholine-N-oxide / H2O; acetone / 15 h 3: pyridine / 24 h / Ambient temperature 4: 0.50 g / NaOCH3 / methanol / 0.5 h / 50 - 60 °C View Scheme

: 80448-05-1
3-[4-(2-methoxyethyl)phenoxy]propylene

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 80 percent / OsO4, N-methylmorpholine-N-oxide / H2O; acetone / 15 h 2: pyridine / 24 h / Ambient temperature 3: 0.50 g / NaOCH3 / methanol / 0.5 h / 50 - 60 °C View Scheme

: 62572-90-1
3-<4-(2-methoxyethyl)phenoxy>-1,2-propanediol

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: pyridine / 24 h / Ambient temperature 2: 0.50 g / NaOCH3 / methanol / 0.5 h / 50 - 60 °C View Scheme

: 108-95-2
phenol

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: 50 percent / AlCl3 / various solvent(s) / 5 h / 70 °C 2: 90 percent / methanol / 24 h / Ambient temperature 3: 96 percent / H2 / 10percent Pd/C / ethanol / 4 h / 2327.2 Torr 4: 85 percent / K2CO3 / acetone / 7 h / Heating 5: 80 percent / OsO4, N-methylmorpholine-N-oxide / H2O; acetone / 15 h 6: pyridine / 24 h / Ambient temperature 7: 0.50 g / NaOCH3 / methanol / 0.5 h / 50 - 60 °C View Scheme

Yield

Multi-step reaction with 7 steps
1: 50 percent / AlCl3 / various solvent(s) / 5 h / 70 °C
2: 90 percent / methanol / 24 h / Ambient temperature
3: 96 percent / H2 / 10percent Pd/C / ethanol / 4 h / 2327.2 Torr
4: 85 percent / K2CO3 / acetone / 7 h / Heating
5: 80 percent / OsO4, N-methylmorpholine-N-oxide / H2O; acetone / 15 h
6: pyridine / 24 h / Ambient temperature
7: 0.50 g / NaOCH3 / methanol / 0.5 h / 50 - 60 °C
View Scheme

: 56718-71-9
4-(2-methoxyethyl)phenol

: 106-89-8
epichlorohydrin

A: C21H28O5

B: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

C: 56718-76-4
(+/-)-1-[4-(2-methoxyethyl)phenoxy]-3-chloro-2-propanol

Conditions

Conditions	Yield
With tetrabutyl-ammonium chloride at 110℃; under 2100.21 Torr; for 0.95h; Flow reactor;

...Expand

: 67843-74-7
(S)-epichlorohydrin

: 56718-71-9
4-(2-methoxyethyl)phenol

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

Conditions

Conditions	Yield
With potassium carbonate In acetone Reflux;

: 75-31-0
isopropylamine

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 51384-51-1
(RS)-metoprolol

Conditions

Conditions	Yield
In ethanol at 50 - 92℃; Temperature; Flow reactor;	99.58%
Stage #1: isopropylamine; 2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane In N,N-dimethyl-formamide at 60℃; for 12h; Sealed tube; Stage #2: With water In N,N-dimethyl-formamide at 60℃; for 12h; Solvent; Temperature; Sealed tube; regioselective reaction;	95%
In water at 80℃; Flow reactor;	93.1%

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 56718-76-4
(+/-)-1-[4-(2-methoxyethyl)phenoxy]-3-chloro-2-propanol

Conditions

Conditions	Yield
With morpholine; 1,3,5-trichloro-2,4,6-triazine In water at 20℃; for 0.5h;	98%
Stage #1: 2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane With β‐cyclodextrin In water; acetone at 60℃; Stage #2: With thionyl chloride In water; acetone at 20℃; for 10h;	91%
With zirconyl chloride In acetonitrile at 20℃; for 1.16667h;	80%
With water; acetyl chloride In dichloromethane for 12h;

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: (RS)-1-bromo-3-[4-(2-methoxy-ethyl)-phenoxy]-propan-2-ol

Conditions

Conditions	Yield
With dimethylbromosulphonium bromide In acetonitrile at 20℃; for 0.333333h;	98%
With acetic acid; lithium bromide In tetrahydrofuran at 20℃; for 12h;

: 108-24-7
acetic anhydride

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: acetic acid 1-acetoxymethyl-2-[4-(2-methoxy-ethyl)-phenoxy]-ethyl ester

Conditions

Conditions	Yield
With ammonium molybdophosphate at 20℃; for 1h;	96%

: 3282-30-2
pivaloyl chloride

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: C17H25ClO4

Conditions

Conditions	Yield
With iron(III) chloride In neat (no solvent) at 20℃; for 0.0833333h; regiospecific reaction;	96%

: 110-15-6
succinic acid

: 75-31-0
isopropylamine

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: metoprolol Succinate

Conditions

Conditions	Yield
Stage #1: isopropylamine; 2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane In ethanol at 50 - 92℃; Flow reactor; Stage #2: succinic acid In ethanol Reflux;	95.6%

...Expand

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 750614-73-4
2-[4-(2-methoxyethyl)phenoxymethyl]thiirane

Conditions

Conditions	Yield
With thiourea; β‐cyclodextrin In water; acetone at 20℃; for 3.5h;	94%
With potassium thioacyanate; β‐cyclodextrin In water; acetone at 20℃; for 4h;	92%
With potassium thioacyanate In various solvent(s) at 20℃; for 0.75h;	89%

: 98-91-9
thiobenzoic acid

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: thiobenzoic acid S-{2-hydroxy-3-[4-(2-methoxy-ethyl)-phenoxy]-propyl} ester

Conditions

Conditions	Yield
With β‐cyclodextrin In water; acetone at 20℃; for 8h;	94%

: 108-98-5
thiophenol

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 934538-08-6
C18H22O3S

Conditions

Conditions	Yield
With magnesium oxide; copper at 20℃; for 0.333333h; chemoselective reaction;	94%

: 139-02-6
sodium phenoxide

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 1-[4-(2-methoxyethyl)phenoxy]-3-phenoxy-2-propanol

Conditions

Conditions	Yield
With β‐cyclodextrin In water; acetone at 60℃; for 8h;	92%
With PEG-400 at 20℃; for 2.5h;	88%

: 106-54-7
p-Chlorothiophenol

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 934538-09-7
C18H21ClO3S

Conditions

Conditions	Yield
With magnesium oxide; copper at 20℃; for 0.333333h; chemoselective reaction;	92%

: 108-98-5
thiophenol

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 1236110-91-0
C18H22O4S

Conditions

Conditions	Yield
Stage #1: thiophenol; 2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane With magnesium oxide; copper at 20℃; Stage #2: With dihydrogen peroxide In water at 20℃; for 1.25h; chemoselective reaction;	91%

: 106-45-6
para-thiocresol

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 1236110-89-6
C19H24O3S

Conditions

Conditions	Yield
With magnesium oxide; copper at 20℃; for 0.333333h; chemoselective reaction;	91%

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 1193-00-6
sodium 4-chlorophenolate

: 1-(4-chlorophenoxy)-3-[4-(2-methoxyethyl)phenoxy]-2-propanol

Conditions

Conditions	Yield
With β‐cyclodextrin In water; acetone at 60℃; for 8h;	90%
With PEG-400 at 20℃; for 3h;	85%

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 507-09-5
thioacetic acid

: thioacetic acid S-{2-hydroxy-3-[4-(2-methoxy-ethyl)-phenoxy]-propyl} ester

Conditions

Conditions	Yield
With β‐cyclodextrin In water; acetone at 20℃; for 8h;	90%

: 106-54-7
p-Chlorothiophenol

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 1236110-93-2
C18H21ClO4S

Conditions

Conditions	Yield
Stage #1: p-Chlorothiophenol; 2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane With magnesium oxide; copper at 20℃; Stage #2: With dihydrogen peroxide In water at 20℃; for 1.25h; chemoselective reaction;	90%

: 104-94-9
4-methoxy-aniline

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 1-[4-(2-methoxy-ethyl)-phenoxy]-3-(4-methoxy-phenylamino)-propan-2-ol

Conditions

Conditions	Yield
With β‐cyclodextrin In water; acetone at 20℃;	89%

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 1-[4-(2-methoxy-ethyl)-phenoxy]-3-nitrooxy-propan-2-ol

Conditions

Conditions	Yield
With bismuth(III) nitrate In acetonitrile at 20℃; for 1.5h;	89%
With zirconyl nitrate In acetonitrile at 20℃; for 5h;	85%

: 106-45-6
para-thiocresol

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 1236110-92-1
C19H24O4S

Conditions

Conditions	Yield
Stage #1: para-thiocresol; 2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane With magnesium oxide; copper at 20℃; Stage #2: With dihydrogen peroxide In water at 20℃; for 1.25h; chemoselective reaction;	89%

: 1122-95-8
sodium 4-methoxyphenolate

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 1-[4-(2-methoxyethyl)phenoxy]-3-(4-methoxyphenoxy)-2-propanol

Conditions

Conditions	Yield
With β‐cyclodextrin In water; acetone at 60℃; for 8h;	88%

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 62572-90-1
3-<4-(2-methoxyethyl)phenoxy>-1,2-propanediol

Conditions

Conditions	Yield
With β‐cyclodextrin In methanol; water at 40℃; for 6h;	85%

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 60-24-2
2-hydroxyethanethiol

: 1236110-90-9
C14H22O4S

Conditions

Conditions	Yield
With magnesium oxide; copper at 20℃; for 0.5h; chemoselective reaction;	85%

: 65-85-0
benzoic acid

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: C19H22O5

Conditions

Conditions	Yield
With sodium hydrogencarbonate In acetonitrile at 50℃; for 6h; Reagent/catalyst; Solvent;	83%

: 645-96-5
Benzeneselenol

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 1-[4-(2-methoxy-ethyl)-phenoxy]-3-phenylselanyl-propan-2-ol

Conditions

Conditions	Yield
Stage #1: 2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane With β‐cyclodextrin In water; acetone Stage #2: Benzeneselenol In water; acetone at 20℃; for 0.583333h;	82%

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

A: (R)-1-[4-(2-methoxyethyl)]phenyl glycerol

B: 105780-38-9
(2S)-2-{[4-(2-Methoxyethyl)phenoxy]methyl}oxirane

C: 133397-54-3
(R)-2-{[4-(2-methoxyethyl)phenoxy]methyl}oxirane

Conditions

Conditions	Yield
With Salen-Co(III)OAc In water Ambient temperature;	A 49% B 45% C n/a

...Expand

: 5856-62-2
(S)-2-aminobutan-1-ol

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

A: (2S)-2-[[(2R)-2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl]amino]-1-butanol

B: (2S)-2-[[(2S)-2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl]amino]-1-butanol

Conditions

Conditions	Yield
In water at 20℃; for 24h;	A 25% B 43%

...Expand

: 4442-59-5
(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)amine

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 1-[(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-amino]-3-[4-(2-methoxy-ethyl)-phenoxy]-propan-2-ol; hydrochloride

Conditions

Conditions	Yield
In methanol for 2h; Heating;	26%

: 120690-14-4
N-(2-aminoethyl)-4-(1H-imidazol-1-yl)benzamide hydrochloride

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

: 128263-89-8
N-[2-[[2-Hydroxy-3-(4-(2-methoxyethyl)phenoxy)propyl]amino]ethyl]-4-(1H-imidazol-1-yl)benzamide

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water at 60℃; for 17h;	11%

Oxirane,2-[[4-(2-methoxyethyl)phenoxy]methyl]- Specification

The Oxirane,2-[[4-(2-methoxyethyl)phenoxy]methyl]-, with the CAS registry number 56718-70-8, is also known as ((p-(2-Methoxyethyl)phenoxy)methyl)oxirane. This chemical's molecular formula is C₁₂H₁₆O₃ and molecular weight is 208.25. What's more, its systematic name is 2-{[4-(2-Methoxyethyl)phenoxy]methyl}oxirane and its EINECS number is 260-353-3. Besides, it belongs to the product categories of Various Metabolites and Impurities; Intermediates & Fine Chemicals; Metabolites & Impurities; Pharmaceuticals.

Physical properties of Oxirane,2-[[4-(2-methoxyethyl)phenoxy]methyl]- are: (1)ACD/LogP: 1.67; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.67; (4)ACD/LogD (pH 7.4): 1.67; (5)ACD/BCF (pH 5.5): 10.85; (6)ACD/BCF (pH 7.4): 10.85; (7)ACD/KOC (pH 5.5): 191.81; (8)ACD/KOC (pH 7.4): 191.81; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 6; (12)Polar Surface Area: 30.99 Å²; (13)Index of Refraction: 1.521; (14)Molar Refractivity: 57.69 cm³; (15)Molar Volume: 189.4 cm³; (16)Polarizability: 22.87×10^-24cm³; (17)Surface Tension: 40.2 dyne/cm; (18)Density: 1.099 g/cm³; (19)Flash Point: 100.1 °C; (20)Enthalpy of Vaporization: 51.9 kJ/mol; (21)Boiling Point: 300.6 °C at 760 mmHg; (22)Vapour Pressure: 0.00199 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O(c1ccc(cc1)CCOC)CC2OC2
(2)InChI: InChI=1/C12H16O3/c1-13-7-6-10-2-4-11(5-3-10)14-8-12-9-15-12/h2-5,12H,6-9H2,1H3
(3)InChIKey: UEOWFGJMGUIGHC-UHFFFAOYSA-N

Product Name

[[p-(2-methoxyethyl)phenoxy]methyl]oxirane

Synthetic route

Oxirane,2-[[4-(2-methoxyethyl)phenoxy]methyl]- Specification

Related Products

Hot Products