Oxymetazoline-hydrochloride: 0 Products found
Name
Oxymetazoline-hydrochloride
EINECS
219-015-0
CAS No.
2315-02-8
Density
1.08g/cm3
Solubility
Melting Point
Formula
C16H24 N2 O . Cl H
Boiling Point
431.9°Cat760mmHg
Molecular Weight
296.88
Flash Point
215°C
Transport Information
UN 2811
Appearance
Safety
Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and HCl. An adrenergic agent.
Risk Codes
R28
Molecular Structure
Hazard Symbols
Synonyms
Phenol,3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl-,monohydrochloride (9CI); Phenol,6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-, hydrochloride (7CI);Phenol, 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-,monohydrochloride (8CI); 2,6-Dimethyl-4-tertiarybutyl-3-hydroxyphenyl)methylimidazolinehydrochloride; 2-(4-tert-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoliniumchloride; 4-Way Nasal 12 Hour Spray; 4-Way Nasal Spray;6-tert-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol hydrochloride; Afrazine;Afrin; Afrin hydrochloride; Allerest 12 Hour Nasal Spray; Dristan Long-LastingNasal Mist; Duration; Duration 12 Hour Nasal Spray; H 990; Iliadin; Nafrine;Nasivin; Neo-Synephrine 12 Hour; Neo-Synephrine 12 Hour NTZ; Nostrilla;Ocuclear; Oxilin; Oxymetazoline chloride; Oxymetazoline hydrochloride; Respir;Sch 9384

History

Formaldehyde was first reported by the Russian chemist Aleksandr Butlerov (1828-1886), but it was conclusively identified by August Wilhelm von Hofmann.

Chemistry

IUPAC Name: 6-Tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol hydrochloride
Molecular Formula: C16H25ClN2O
Formula Weight: 296.84g/mol
EINECS: 219-015-0
Flash Point: 215 °C
Enthalpy of Vaporization: 71.41 kJ/mol
Boiling Point: 431.9 °C at 760 mmHg
Vapour Pressure: 4.59E-08 mmHg at 25°C
Form: solid
Color: white
H bond acceptors: 3
Freely Rotating Bonds: 4
Synonyms of  Afrin hydrochloride (2315-02-8): 2-(4-t-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoliniumchloride ; 2,6-Dimethyl-2-(4-tertiarybutyl-3-hydroxyphenyl)methylimidazolinehydrochlori ; 6-t-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-phenohydrochloride ; 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenolhydrochloride ; Afrazine ; Duration ; Iliadinhydrochloride
Product Categories of  Afrin hydrochloride (2315-02-8): Adrenoceptor
Structure of  Afrin hydrochloride (2315-02-8):
 

Uses

It is used in local vasoconstriction drugs.
It is also used as allergic conjunctivitis, allergic rhinitis, acute and chronic
rhinitis and so on.

Toxicity

1.    

ipr-rat TDLo:1800 µg/kg (1-3D preg):REP

    IJMRAQ    Indian Journal of Medical Research. 67 (1978),478.
2.    

orl-rat LD50:680 µg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 30 (1980),1760.
3.    

scu-rat LD50:1630 µg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 11 (1961),1016.
4.    

ivn-rat LD50:1070 µg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 11 (1961),1016.
5.    

orl-mus LD50:4700 µg/kg

    OYYAA2    Oyo Yakuri. Pharmacometrics. 1 (1967),74.
6.    

ipr-mus LD50:48 mg/kg

    FRPPAO    Farmaco, Edizione Pratica. 21 (1966),204.
7.    

scu-mus LD50:34 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 11 (1961),1016.
8.    

ivn-mus LD50:2700 µg/kg

    OYYAA2    Oyo Yakuri. Pharmacometrics. 1 (1967),74.

Safety

Hazard Codes: T+ Very
Risk Statements: 28
R28: Very toxic if swallowed.
Safety Statements: 22-28-36/37/39-45 
S22: Do not breathe dust. 
S28: After contact with skin, wash immediately with plenty of soap-suds. 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
Hazard Class: 6.1(a)

Others

It will be kept in ventilated, cold ,dry place,and separately from
raw materials and food.