4-mercapto-4-methylvaleronitrile
4-mercapto-4-dimethylpentanoic acid
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water Heating / reflux; | 39% |
With sodium hydroxide In ethanol Heating; | 10 g |
2,2-dimethylthiirane
carbon dioxide
4-mercapto-4-dimethylpentanoic acid
Conditions | Yield |
---|---|
With sodium hydroxide; n-butyllithium; sodium sulfate In tetrahydrofuran; hydrogenchloride; ethanol; water; ethyl acetate; acetonitrile | 39% |
4-mercapto-4-dimethylpentanoic acid
Conditions | Yield |
---|---|
With hydrogen sulfide; sulfur at 180℃; |
thiourea
methyl 4-hydroxy-4-methylpentanoate
4-mercapto-4-dimethylpentanoic acid
Conditions | Yield |
---|---|
Stage #1: thiourea; methyl 4-hydroxy-4-methylpentanoate With hydrogenchloride In water for 24h; Reflux; Stage #2: With water; lithium hydroxide In methanol Reflux; |
4-mercapto-4-dimethylpentanoic acid
11-amino-3,6,9-trioxaundecanol
Conditions | Yield |
---|---|
Stage #1: 4-mercapto-4-dimethylpentanoic acid With dmap; acetic anhydride; triethylamine In acetonitrile for 0.533333h; Stage #2: 11-amino-3,6,9-trioxaundecanol In acetonitrile for 18h; | 96% |
4-mercapto-4-dimethylpentanoic acid
4-(((E)-2-((1R,8S,Z)-8-(((2R,3R,4R,5S,6R)-5-((((2S,4S,5S,6R)-5-((4-(((2S,3R,4R,5S,6S)-3,5-dihydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3-iodo-5,6-dimethoxy-2-methylbenzoyl)thio)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)amino)-3-(((2S,4S,5S)-5-(N-ethylacetamido)-4-methoxytetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-1-hydroxy-10-((methoxycarbonyl)amino)-11-oxobicyclo[7.3.1]trideca-4,9-dien-2,6-diyn-13-ylidene)ethyl)disulfanyl)-4-methylpentanoic acid
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at -15 - 20℃; | 90.5% |
2,2'-dipyridyldisulphide
4-mercapto-4-dimethylpentanoic acid
Conditions | Yield |
---|---|
With sodium phosphate In methanol for 6h; pH=7.5; | 87% |
In methanol; aq. phosphate buffer for 6h; pH=7.5; | 87% |
In methanol; aq. phosphate buffer for 6h; pH=7.5; | 87% |
In methanol; aq. phosphate buffer for 6h; pH=7.5; | 87% |
methanethiosulfonic acid S-methyl ester
4-mercapto-4-dimethylpentanoic acid
N-methyl-N-[4-methyl-(4-methyldithio)-1-oxopropyl]-L-alanine
Conditions | Yield |
---|---|
In methanol at 0 - 20℃; pH=6 - 7.5; aq. phosphate buffer; | 83% |
With sodium carbonate In ethanol; water at 20℃; for 3h; | 70% |
With sodium carbonate In ethanol; water at 0℃; for 3h; | 70% |
Conditions | Yield |
---|---|
Stage #1: 4-mercapto-4-dimethylpentanoic acid With dmap; acetic anhydride; triethylamine In acetonitrile for 0.5h; Stage #2: 2-(2-Aminoethoxy)ethanol In acetonitrile for 20h; | 69% |
Stage #1: 4-mercapto-4-dimethylpentanoic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane for 0.166667h; Stage #2: 2-(2-Aminoethoxy)ethanol In dichloromethane for 19h; |
Conditions | Yield |
---|---|
Stage #1: 4-mercapto-4-dimethylpentanoic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.166667h; Stage #2: N-BOC-1,2-diaminoethane In dichloromethane for 24h; | 67% |
4-mercapto-4-dimethylpentanoic acid
tert-butyl N-methyl-N-<2-(methylamino)ethyl>carbamate
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 24h; Inert atmosphere; | 65% |
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide; acetonitrile at -15 - 20℃; for 0.5h; | 61% |
Conditions | Yield |
---|---|
Stage #1: 4-mercapto-4-dimethylpentanoic acid With dmap; acetic anhydride; triethylamine In acetonitrile for 1h; Stage #2: Propargylamine In acetonitrile | 59% |
Stage #1: 4-mercapto-4-dimethylpentanoic acid With dmap; acetic anhydride; triethylamine In acetonitrile for 1h; Stage #2: Propargylamine In acetonitrile | 59% |
Stage #1: 4-mercapto-4-dimethylpentanoic acid With dmap; acetic anhydride; triethylamine In acetonitrile for 1h; Stage #2: Propargylamine In acetonitrile | 59% |
Conditions | Yield |
---|---|
Stage #1: 4-mercapto-4-dimethylpentanoic acid With dmap; acetic anhydride; triethylamine In acetonitrile for 1h; Stage #2: benzylamine In acetonitrile | 59% |
Stage #1: 4-mercapto-4-dimethylpentanoic acid With dmap; acetic anhydride; triethylamine In acetonitrile for 1h; Stage #2: benzylamine In acetonitrile | 59% |
4-mercapto-4-dimethylpentanoic acid
2-(2-(Pyridin-2-yl)disulfanyl)ethanol
Conditions | Yield |
---|---|
With acetic acid In methanol at 45℃; for 120h; | 58.1% |
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In chloroform at 20 - 60℃; for 75.5h; | 54% |
4-((2-pyridyl)dithio)butan-1-ol
4-mercapto-4-dimethylpentanoic acid
Conditions | Yield |
---|---|
With acetic acid In methanol at 20℃; for 16h; | 50% |
With acetic acid In methanol at 20℃; for 16h; | 50% |
Conditions | Yield |
---|---|
Stage #1: 4-mercapto-4-dimethylpentanoic acid With dmap; acetic anhydride; triethylamine In acetonitrile at 20℃; for 0.5h; Inert atmosphere; Stage #2: C15H23NO2 In acetonitrile at 20℃; | 49% |
Stage #1: 4-mercapto-4-dimethylpentanoic acid With dmap; acetic anhydride; triethylamine In acetonitrile at 20℃; for 0.5h; Inert atmosphere; Stage #2: C15H23NO2 In acetonitrile at 20℃; | 49% |
4-mercapto-4-dimethylpentanoic acid
Conditions | Yield |
---|---|
With iodine |
4-mercapto-4-dimethylpentanoic acid
N-methyl-N-[4-methyl-(4-methyldithio)-1-oxopentyl]-L-alanine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 70 percent / sodium carbonate / ethanol; H2O / 3 h / 20 °C 2: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH2Cl2 / 2 h 3: triethylamine / H2O; 1,2-dimethoxy-ethane / 2 h View Scheme |
4-mercapto-4-dimethylpentanoic acid
2,5-dioxopyrrolidin-1-yl 4-methyl-4-(methyldisulfanyl)pentanoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 70 percent / sodium carbonate / ethanol; H2O / 3 h / 20 °C 2: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH2Cl2 / 2 h View Scheme |
4-mercapto-4-dimethylpentanoic acid
N2′-deacetyl-N2′-(4-mercapto-4-methyl-1-oxopentyl)maytansine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 70 percent / sodium carbonate / ethanol; H2O / 3 h / 20 °C 2: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH2Cl2 / 2 h 3: triethylamine / H2O; 1,2-dimethoxy-ethane / 2 h 4: 36 percent / dicyclohexylcarbodiimide; ZnCl2 / CH2Cl2; diethyl ether / 2 h / 20 °C 5: 97 percent / dithiothreitol / methanol; ethyl acetate; aq. phosphate buffer / 3 h / pH 7.5 View Scheme |
4-mercapto-4-dimethylpentanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 70 percent / sodium carbonate / ethanol; H2O / 3 h / 20 °C 2: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH2Cl2 / 2 h 3: triethylamine / H2O; 1,2-dimethoxy-ethane / 2 h 4: dicyclohexylcarbodiimide; ZnCl2 / CH2Cl2; diethyl ether / 2 h / 20 °C 5: dithiothreitol; EDTA / methanol; ethyl acetate; aq. phosphate buffer / 20 °C / pH 7.5 View Scheme |
4-mercapto-4-dimethylpentanoic acid
N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]maytansine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 70 percent / sodium carbonate / ethanol; H2O / 3 h / 20 °C 2: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH2Cl2 / 2 h 3: triethylamine / H2O; 1,2-dimethoxy-ethane / 2 h 4: 36 percent / dicyclohexylcarbodiimide; ZnCl2 / CH2Cl2; diethyl ether / 2 h / 20 °C View Scheme |
4-mercapto-4-dimethylpentanoic acid
N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]-D-maytansine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 70 percent / sodium carbonate / ethanol; H2O / 3 h / 20 °C 2: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH2Cl2 / 2 h 3: triethylamine / H2O; 1,2-dimethoxy-ethane / 2 h 4: dicyclohexylcarbodiimide; ZnCl2 / CH2Cl2; diethyl ether / 2 h / 20 °C View Scheme |
4-mercapto-4-dimethylpentanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 70 percent / sodium carbonate / ethanol; H2O / 3 h / 20 °C 2: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH2Cl2 / 2 h 3: triethylamine / H2O; 1,2-dimethoxy-ethane / 2 h 4: 36 percent / dicyclohexylcarbodiimide; ZnCl2 / CH2Cl2; diethyl ether / 2 h / 20 °C 5: 97 percent / dithiothreitol / methanol; ethyl acetate; aq. phosphate buffer / 3 h / pH 7.5 6: 57 percent / EDTA / methanol; aq. phosphate buffer / 3 h / pH 7.6 View Scheme |
4-mercapto-4-dimethylpentanoic acid
5,5'-dinitro-2,2'-disulfanediyl-bis-pyridine
N,N-dimethyl-formamide
4-methyl-4-(5-nitro-pyridin-2-yldithio)pentanoic Acid
Conditions | Yield |
---|---|
With 4-methyl-morpholine In tetrahydrofuran; ethyl acetate |
4-mercapto-4-dimethylpentanoic acid
1-(1S)-(chloromethyl)-5-hydroxy-3-{5-[(5-(4-(methyldisulfanyl)-3,3-dimethylbutyryl)indol-2-ylcarbonyl)amino]indole-2-carbonyl}-1,2-dihydro-3H-benz[e]indole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: methanol / 0 - 20 °C / pH 6 - 7.5 / aq. phosphate buffer 2: N,N-dimethyl acetamide; 1,2-dichloro-ethane / Inert atmosphere 3: triethylsilane; trifluoroacetic acid / dichloromethane / 1 h 4: N,N-dimethyl acetamide; 1,2-dichloro-ethane / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: methanol / 0 - 20 °C / pH 6 - 7.5 / aq. phosphate buffer 2: N,N-dimethyl acetamide; 1,2-dichloro-ethane / Inert atmosphere View Scheme |
4-mercapto-4-dimethylpentanoic acid
t-butyl 5-[5-(4-methyldithio-3,3-dimethylbutyryl)indol-2-yl-carbonylamino]indole-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: methanol / 0 - 20 °C / pH 6 - 7.5 / aq. phosphate buffer 2: N,N-dimethyl acetamide; 1,2-dichloro-ethane / Inert atmosphere View Scheme |
4-mercapto-4-dimethylpentanoic acid
5-[5'-(3-(methyldithio)-3,3-dimethyl butyryl)indol-2-ylcarbonylamino]indole-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: methanol / 0 - 20 °C / pH 6 - 7.5 / aq. phosphate buffer 2: N,N-dimethyl acetamide; 1,2-dichloro-ethane / Inert atmosphere 3: triethylsilane; trifluoroacetic acid / dichloromethane / 1 h View Scheme |
4-mercapto-4-dimethylpentanoic acid
1-[S]-(chloromethyl)-5-phosphonoxy-3-{{5-[5-(4-methyldithio-3,3-dimethylbutyryl)indol-2-ylcarbonylamino]indole-2-yl}-carbonyl}-1,2-dihydro-3H-benz[e]indole
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: methanol / 0 - 20 °C / pH 6 - 7.5 / aq. phosphate buffer 2.1: N,N-dimethyl acetamide; 1,2-dichloro-ethane / Inert atmosphere 3.1: triethylsilane; trifluoroacetic acid / dichloromethane / 1 h 4.1: N,N-dimethyl acetamide; 1,2-dichloro-ethane / Inert atmosphere 5.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / tetrahydrofuran; acetonitrile / 2.5 h / 0 °C / Inert atmosphere 5.2: pH 7 / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: methanol / 0 - 20 °C / pH 6 - 7.5 / aq. phosphate buffer 2.1: N,N-dimethyl acetamide; 1,2-dichloro-ethane / Inert atmosphere 3.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / tetrahydrofuran; acetonitrile / 2.5 h / 0 °C / Inert atmosphere 3.2: pH 7 / Inert atmosphere View Scheme |
The Pentanoicacid, 4-mercapto-4-methyl-, with the CAS registry number 140231-31-8, is also known as 4-Mercapto-4-methylpentanoic acid. This chemical's molecular formula is C6H12O2S and molecular weight is 148.22. What's more, its systematic name is 4-Methyl-4-sulfanylpentanoic acid and it belongs to the product category of Small Molecule.
Physical properties of Pentanoicacid, 4-mercapto-4-methyl- are: (1)ACD/LogP: 1.46; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0; (4)ACD/LogD (pH 7.4): -1; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 13; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 76.1 Å2; (13)Index of Refraction: 1.488; (14)Molar Refractivity: 39.273 cm3; (15)Molar Volume: 136.298 cm3; (16)Polarizability: 15.569×10-24 cm3; (17)Surface Tension: 38.544 dyne/cm; (18)Density: 1.087 g/cm3; (19)Flash Point: 108.89 °C; (20)Enthalpy of Vaporization: 54.384 kJ/mol; (21)Boiling Point: 256.438 °C at 760 mmHg; (22)Vapour Pressure: 0.005 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)CCC(S)(C)C
(2)InChI: InChI=1/C6H12O2S/c1-6(2,9)4-3-5(7)8/h9H,3-4H2,1-2H3,(H,7,8)
(3)InChIKey: SYIFSIGCMOMQRB-UHFFFAOYSA-N
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