4-Hydroxy-2-(trifluoromethyl)thiophene
Conditions | Yield |
---|---|
at 100℃; for 3.5h; Decarboxylation; | 82% |
82% |
methyl 3-hydroxy-5-(trifluoromethyl)thiophene-2-carboxylate
4-Hydroxy-2-(trifluoromethyl)thiophene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 65 percent / aq. NaOH / 3 h / Heating 2: 82 percent / 3.5 h / 100 °C View Scheme |
trifluoromethylsulfonic anhydride
4-Hydroxy-2-(trifluoromethyl)thiophene
4-trifluoromethanesulfonate-2-trifluoromethylthiophene
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 0 - 20℃; for 3h; | 92% |
N-{[5-methyl-4-(methylsulfonyl)pyrimidin-2-yl]methyl}cyclopropane-carboxamide
4-Hydroxy-2-(trifluoromethyl)thiophene
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 8h; Heating / reflux; | 18% |
2,6-difluoro pyridine
4-Hydroxy-2-(trifluoromethyl)thiophene
2-fluoro-6-(2-trifluoromethyl-4-thienyloxy)pyridine
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20 - 80℃; for 4h; |
The Thiophene-3-ol,5-(trifluoromethyl)-, also known as 3(2H)-Thiophenone, 5-(trifluoromethyl)-, is an organic compound with the formula C5H3F3OS. With the CAS registry number 217959-45-0, its IUPAC name is 5-(trifluoromethyl)thiophen-3-one.
Physical properties of Thiophene-3-ol,5-(trifluoromethyl)-: (1)ACD/LogP: 2.08; (2)ACD/LogD (pH 5.5): 2.08; (3)ACD/LogD (pH 7.4): 2.08; (4)ACD/BCF (pH 5.5): 22.36; (5)ACD/BCF (pH 7.4): 22.36; (6)ACD/KOC (pH 5.5): 321.75; (7)ACD/KOC (pH 7.4): 321.75; (8)#H bond acceptors: 1; (9)Index of Refraction: 1.482; (10)Molar Refractivity: 31.12 cm3; (11)Molar Volume: 109 cm3; (12)Surface Tension: 35.2 dyne/cm; (13)Density: 1.541 g/cm3; (14)Flash Point: 42.1 °C; (15)Enthalpy of Vaporization: 38.3 kJ/mol; (16)Boiling Point: 145.9 °C at 760 mmHg; (17)Vapour Pressure: 4.75 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1C(=O)C=C(S1)C(F)(F)F
(2)InChI: InChI=1S/C5H3F3OS/c6-5(7,8)4-1-3(9)2-10-4/h1H,2H2
(3)InChIKey: CYTOKNSEVPOFNF-UHFFFAOYSA-N
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