-
Name
Xipamide
- EINECS 238-216-4
- CAS No. 14293-44-8
- Article Data2
- CAS DataBase
- Density 1.477 g/cm3
- Solubility 58mg/L(25 oC)
- Melting Point 255-256 °C
- Formula C15H15ClN2O4S
- Boiling Point
- Molecular Weight 354.814
- Flash Point
- Transport Information
- Appearance
- Safety 26
- Risk Codes 36/37/38
-
Molecular Structure
- Hazard Symbols Xi
- Synonyms 2',6'-Salicyloxylidide,4-chloro-5-sulfamoyl- (8CI);Aquaphor;Aquaphor (diuretic);BE 1293;BEI 1293;Chronexan;Diurex (Lacer);Diurexan;Lumitens;MJF 10938;
- PSA 117.87000
- LogP 4.41620
Xipamide Chemical Properties
Product Name: Xipamide (CAS NO.14293-44-8)
MF: C15H15ClN2O4S
MW: 354.81
Index of Refraction: 1.652
Melting Point: 255-256 °C
EINECS: 238-216-4
Index of Refraction: 1.652
Molar Refractivity: 87.89 cm3
Molar Volume: 40.1 cm3
Surface Tension: 67.1 dyne/cm
Density: 1.477 g/cm3
XLogP3-AA: 2.9
H-Bond Donor: 3
H-Bond Acceptor: 5
Structure Descriptors of Xipamide (CAS NO.14293-44-8):
IUPAC Name: 4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide
Canonical SMILES: CC1=C(C(=CC=C1)C)NC(=O)C2=CC(=C(C=C2O)Cl)S(=O)(=O)N
InChI: InChI=1S/C15H15ClN2O4S/c1-8-4-3-5-9(2)14(8)18-15(20)10-6-13(23(17,21)22)11(16)7-12(10)19/h3-7,19H,1-2H3,(H,18,20)(H2,17,21,22)
InChIKey: MTZBBNMLMNBNJL-UHFFFAOYSA-N
Product Categories: APIs; Xipamide
Xipamide Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | > 50mg/kg (50mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 245, 1975. | |
| dog | LD50 | oral | > 1500mg/kg (1500mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 245, 1975. | |
| mouse | LD50 | intraperitoneal | 520mg/kg (520mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 245, 1975. |
| mouse | LD50 | oral | 877mg/kg (877mg/kg) | United States Patent Document. Vol. #4490368, | |
| mouse | LD50 | subcutaneous | 1480mg/kg (1480mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 245, 1975. |
| rat | LD50 | intraperitoneal | 320mg/kg (320mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 245, 1975. |
| rat | LD50 | oral | 1640mg/kg (1640mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 245, 1975. |
Xipamide Safety Profile
Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of Cl−, SOx, and NOx.
Xipamide Specification
Xipamide , its CAS NO. is 14293-44-8, the synonyms are 4-Chloro-2',6'-dimethyl-5-sulfamoylsalicylanilide ; 4-Chloro-5-sulfamylsalicyloyl-2',6'-dimethylanilide ; 4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide ; 5-(Aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxybenzamide ; Benzamide, 5-(aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy- ; 2',6'-Salicyloxylidide, 4-chloro-5-sulfamoyl- .
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