Product Name

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  • Name

    Xylazine

  • EINECS 230-902-1
  • CAS No. 7361-61-7
  • Density 1.15 g/cm3
  • Solubility
  • Melting Point 140 °C
  • Formula C12H16N2S
  • Boiling Point 334.2 °C at 760 mmHg
  • Molecular Weight 220.338
  • Flash Point 155.9 °C
  • Transport Information
  • Appearance
  • Safety 45-37/39-26
  • Risk Codes 25-36/37/38
  • Molecular Structure Molecular Structure of 7361-61-7 (Xylazine)
  • Hazard Symbols ToxicT,IrritantXi
  • Synonyms 4H-1,3-Thiazine,5,6-dihydro-2-(2,6-xylidino)- (7CI,8CI);2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-1,3-thiazine;Anased;BAY 1470;Primazine;Sedomin;Wh 7286;Xylazine;
  • PSA 49.69000
  • LogP 2.71680

Synthetic route

1-(2,6-dimethylphenyl)-3-(3-propanol)thiourea

1-(2,6-dimethylphenyl)-3-(3-propanol)thiourea

xylazine
7361-61-7

xylazine

Conditions
ConditionsYield
With hydrogenchloride In water at 80 - 95℃; Industrial scale;95%
2,6-dimethylaniline
87-62-7

2,6-dimethylaniline

xylazine
7361-61-7

xylazine

Conditions
ConditionsYield
With acetic anhydride In tetrahydrofuran; ethanol113.8 g (84%)
tetrahydrofuran ("THF")

tetrahydrofuran ("THF")

2,6-dimethylphenylisothiocyanate
19241-16-8

2,6-dimethylphenylisothiocyanate

propan-1-ol-3-amine
156-87-6

propan-1-ol-3-amine

xylazine
7361-61-7

xylazine

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide In water; acetone
2,6-dimethylphenylisothiocyanate
19241-16-8

2,6-dimethylphenylisothiocyanate

propan-1-ol-3-amine
156-87-6

propan-1-ol-3-amine

xylazine
7361-61-7

xylazine

Conditions
ConditionsYield
With hydrogenchloride In water16.3 g (80%)
N-(2,6-dimethylphenyl)acetamide
2198-53-0

N-(2,6-dimethylphenyl)acetamide

xylazine
7361-61-7

xylazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydride / tetrahydrofuran; toluene / 0.5 h / Industrial scale
2: 50 - 80 °C / Industrial scale
3: hydrogenchloride / water / 80 - 95 °C / Industrial scale
View Scheme
ammonium hydroxide
1336-21-6

ammonium hydroxide

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

xylazine
7361-61-7

xylazine

isopropyl alcohol
67-63-0

isopropyl alcohol

2,6-dimethylaniline
87-62-7

2,6-dimethylaniline

2,6-dimethylphenylisothiocyanate
19241-16-8

2,6-dimethylphenylisothiocyanate

Conditions
ConditionsYield
With carbon disulfide In propan-1-ol; water55.2%
gloutaric dichloride
2873-74-7

gloutaric dichloride

xylazine
7361-61-7

xylazine

C17H21ClN2O2S

C17H21ClN2O2S

Conditions
ConditionsYield
With triethylamine at 4℃;
benzoyl chloride
98-88-4

benzoyl chloride

xylazine
7361-61-7

xylazine

N-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-N-(2,6-dimethyl-phenyl)-benzamide
29280-54-4

N-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-N-(2,6-dimethyl-phenyl)-benzamide

Conditions
ConditionsYield
With pyridine
4-methoxy-benzoyl chloride
100-07-2

4-methoxy-benzoyl chloride

xylazine
7361-61-7

xylazine

N-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-N-(2,6-dimethyl-phenyl)-4-methoxy-benzamide
29280-56-6

N-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-N-(2,6-dimethyl-phenyl)-4-methoxy-benzamide

Conditions
ConditionsYield
With pyridine
ortho-toluoyl chloride
933-88-0

ortho-toluoyl chloride

xylazine
7361-61-7

xylazine

N-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-N-(2,6-dimethyl-phenyl)-2-methyl-benzamide
29280-58-8

N-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-N-(2,6-dimethyl-phenyl)-2-methyl-benzamide

Conditions
ConditionsYield
With pyridine
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

xylazine
7361-61-7

xylazine

A

(5,6-dihydro-4H-[1,3]thiazin-2-yl)-(2,6-dimethyl-phenyl)-carbamic acid ethyl ester
40523-99-7

(5,6-dihydro-4H-[1,3]thiazin-2-yl)-(2,6-dimethyl-phenyl)-carbamic acid ethyl ester

B

2-((Z)-2,6-dimethyl-phenylimino)-[1,3]thiazinane-3-carboxylic acid ethyl ester
67057-44-7

2-((Z)-2,6-dimethyl-phenylimino)-[1,3]thiazinane-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With pyridine

Xylazine Specification

The Xylazine is an organic compound with the formula C12H16N2S. The IUPAC name of this chemical is N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine. With the CAS registry number 7361-61-7, it is also named as 4H-1,3-thiazin-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro-. The product's classification codes are Adrenergic Agents; Adrenergic Agonists; Adrenergic alpha-agonists; Drug / Therapeutic Agent; Human Data; Neurotransmitter Agents. Xylazine is a drug that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals

Physical properties about Xylazine are: (1)ACD/LogP: 2.71; (2)ACD/LogD (pH 5.5): 0.93; (3)ACD/LogD (pH 7.4): 2.26; (4)ACD/BCF (pH 5.5): 1.13; (5)ACD/BCF (pH 7.4): 24.04; (6)ACD/KOC (pH 5.5): 11.82; (7)ACD/KOC (pH 7.4): 252.72; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 1; (11)Index of Refraction: 1.611; (12)Molar Refractivity: 66.298 cm3; (13)Molar Volume: 190.932 cm3; (14)Polarizability: 26.282 10-24cm3; (15)Surface Tension: 40.6339988708496 dyne/cm; (16)Density: 1.154 g/cm3; (17)Flash Point: 155.944 °C; (18)Enthalpy of Vaporization: 57.718 kJ/mol; (19)Boiling Point: 334.241 °C at 760 mmHg

Uses of Xylazine: In veterinary anesthesia, Xylazine is often used in combination with ketamine. It is a drug that is used for anesthesia, sedation, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. As with other α2 agonists, adverse effects include bradycardia, conduction disturbances and myocardial depression. As an emetic, it is desirable to remove a substance from a cat's stomach.

When you are using this chemical, please be cautious about it as the following:
It is toxic if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)InChI=1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14);
(2)InChIKey=BPICBUSOMSTKRF-UHFFFAOYSA-N;
(3)Smilesc1(NC2=NCCCS2)c(cccc1C)CThe toxicity data is as follows:

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 18mg/kg (18mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#10054,
mouse LD50 oral 240mg/kg (240mg/kg)   Deutsche Tieraerztliche Wochenschrift. Vol. 75, Pg. 565, 1968.
 
mouse LD50 subcutaneous 121mg/kg (121mg/kg)   Deutsche Tieraerztliche Wochenschrift. Vol. 75, Pg. 565, 1968.
 
rat LD50 oral 130mg/kg (130mg/kg)   Deutsche Tieraerztliche Wochenschrift. Vol. 75, Pg. 565, 1968.
 
women TDLo intramuscular 734ug/kg (.734mg/kg) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

CARDIAC: PULSE RATE 

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
American Journal of Emergency Medicine. Vol. 4, Pg. 222, 1986.
 
women TDLo intramuscular 22mg/kg (22mg/kg) LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING

CARDIAC: PULSE RATE 

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
American Journal of Emergency Medicine. Vol. 4, Pg. 222, 1986.
 
women TDLo oral 8mg/kg (8mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

CARDIAC: PULSE RATE
Clinical Toxicology. Vol. 18, Pg. 663, 1981.
 

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