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104987-11-3 Tacrolimus FK-506
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Tacrolimus | |
CAS No.: | 104987-11-3 |
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Synonyms: | |
Formula: | C44H69NO12 |
Exact Mass: | 803.48200 |
Molecular Weight: | 804.01800 |
PSA: | 178.36000 |
LogP: | 4.57690 |
Tacrolimus Usage And Synthesis |
Chemical Properties | White Crystalline Solid |
Usage | An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. |
Usage | FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system |
Usage | Tacrolimus (fujimycin) was discovered as a potent inhibitor of IL2 production in a targeted search for novel immunosuppressants. Tacrolimus acts by blocking T cell proliferation in vitro by inhibiting the generation of several lymphokines, notably the original target IL-2. Tacrolimus inhibits the activity of FK-506 binding protein, Ca2+-dependent phosphatase and calcineurin, and activates NF-κB through phosphorylation and degradation of IκBα. |
Usage | treatment of Cushing's syndrome |
Usage | For use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart, |
PropertieFeedback
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Appearance & Physical State: | White or off-white crystalline powder |
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Density: | 1.19 g/cm3 |
Melting Point: | 113-115ºC |
Boiling Point: | 871.7ºC at 760 mmHg |
Flash Point: | 481ºC |
Refractive Index: | 1.549 |
Storage Condition: | -20ºC |
Vapor Pressure: | 1.73E-35mmHg at 25°C |
Safety InfoFeedback
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RTECS: | KD4201200 |
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Safety Statements: | S45-S36-S26 |
WGK Germany: | 3 |
RIDADR: | UN 2811 6 |
Risk Statements: | R25; R36/37/38 |
Hazard Codes: | Xi; T |
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