2444-46-4 Nonivamide

Superiority:

Product Name: Nonivamide
Synonyms: casaicin;Capasaicn;nonivamide powder;Nonivamide(Synthetic Capsaicin);N-((Hydroxy-3-methoxyphenyl)methyl)4-nonanamide;N-Nonanoyl vanillylamide;Nonanamide, N-((4-hydroxy-3-methoxyphenyl)meth;SYNTHETIC CAPSAICIN
CAS: 2444-46-4
MF: C17H27NO3
MW: 293.4
EINECS: 219-484-1
Product Categories: Inhibitors;API;Plant extract;Herb extract;INORGANIC & ORGANIC CHEMICALS;Anilines, Aromatic Amines and Nitro Compounds
Mol File: 2444-46-4.mol

Nonivamide Chemical Properties
Melting point  54°C
Boiling point  200-210 °C(Press: 0.05 Torr)
density  1,1 g/cm3
FEMA  2787 | NONANOYL 4-HYDROXY-3-METHOXYBENZYLAMIDE
Fp  190°C
storage temp.  2-8°C
solubility  methanol: 100 mg/mL, clear to slightly hazy
pka 9.76±0.20(Predicted)
form  powder
color  white to off-white
JECFA Number 1599
BRN  2144300
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey RGOVYLWUIBMPGK-UHFFFAOYSA-N
CAS DataBase Reference 2444-46-4(CAS DataBase Reference)
EPA Substance Registry System Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]- (2444-46-4)
Safety Information
Hazard Codes  T,Xi
Risk Statements  25-36/37/38-43
Safety Statements  26-45-37/39-36/37
RIDADR  UN 3462 6.1/PG 2
WGK Germany  3
RTECS  RA5998000
F  19
HazardClass  6.1
PackingGroup  II
HS Code  29242990

Nonivamide Usage And Synthesis
Description Nonivamide is also called pelargonic acid vanillylamide or PAVA. It is a capsaicinoid. Nonivamide, isolated from peppers, is a naturally occurring analog of capsaicin (sc-3577). Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A. Nonivamide is with lower TRPV1 binding affinity, thus, a reduced pungency (9 200 000 scoville heat units) compared to capsaicin (16 000 000 scoville heat units).
Nonivamide is used in the food production to add a hot sensation to flavoring agents and spice mixtures. It is also used in the sweets and confectionary industries to add hot sensation into products. In pharmaceutical industries, nonivamide is used as a cheaper alternative for capsaicin. Warming or heating ointment of nonivamide is used for temporary relief of pain from conditions such as rheumatism, arthritis, lumbao, muscular aches, sprains and strains, sporting injuries and other conditions where local warmth is beneficial. Finalgon is one of the common product utilizing nonivamide for this purpose. Nonivamide is also used as an incapacitant spray, affecting the assailed person’s eyes, causing intense pain and swelling.