976-71-6 Canrenone

Superiority:

Product Name: Canrenone
Synonyms: 11614r.p;17-(2-Carboxyethyl)17-hydroxy-3-oxoandrosta-4,6-dienelactone;17-(2-Carboxyethyl)17-hydroxyandrosta-4,6-dien-3-onelactone;17-hydroxy-3-oxo-,gamma-lactone,(17-alpha)-pregna-6-diene-21-carboxylicacid;17-Hydroxy-3-oxo-17-pregna-4,6-diene-21-carboxylicacid-lactone;kanlitong;(1R,3aS,3bR,9aR,9bS,11aS)-9a,11a-dimethyl-2,3,3a,3b,7,8,9,9a,9b,10,11,11a-dodecahydrospiro[cyclopenta[a]phenanthrene-1,2';-oxolane]-5'
CAS: 976-71-6
MF: C22H28O3
MW: 340.46
EINECS: 213-554-5
Product Categories: Spironolacrone;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;ASMANEX
Mol File: 976-71-6.mol

Canrenone Chemical Properties
Melting point  158-1600C
alpha  D +24.5° (chloroform)
Boiling point  416.25°C (rough estimate)
density  1.1236 (rough estimate)
refractive index  1.5000 (estimate)
storage temp.  Store at RT
solubility  DMSO: soluble20mg/mL, clear
form  powder
color  white to beige
optical activity [α]/D +17 to +24°, c = 1 in chloroform-d
Water Solubility  272.4ug/L(25 ºC)
CAS DataBase Reference 976-71-6
NIST Chemistry Reference Canrenone(976-71-6)
Safety Information
Hazard Codes  Xn,N
Risk Statements  40-51/53
Safety Statements  36/37-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
HS Code  29329990
MSDS Information
Canrenone Usage And Synthesis
Chemical Properties Pale yellow to pale Green Solid
Uses Aldosterone antagonist. Diuretic
Uses antiinflammatory, glucocorticoid
Brand name Luvion.
World Health Organization (WHO) Canrenone, which has aldosterone antagonist activity, is a major metabolite of spironolactone and the major metabolite of potassium canrenoate. See WHO comments for potassium canrenoate and spironolactone.
Biological Activity Mineralocorticoid receptor antagonist. Active metabolite of spironolactone ((7a,17a)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid g-lactone ).