67392-87-4 Drospirenone

Superiority:

Product Name: Drospirenone
Synonyms: 17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone;7β-(HydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21,17-carbolactone;Drospirenone(Dihydrospirorenone);Drospirenone (USP32);Spiro[17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-17,2'(5'H)-furan]-3,5'(2H)-dione;6β,7β:15β,16β -Dimethylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone;67392-87-4;Drospirenone, >=98%
CAS: 67392-87-4
MF: C24H30O3
MW: 366.4932
EINECS: 266-679-2
Product Categories: REBETOL;Other APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Steroid and Hormone
Mol File: 67392-87-4.mol

Drospirenone Chemical Properties
Melting point  196-200°C
alpha  -180 º (c=0.5, chloroform)
Boiling point  552.2±50.0 °C(Predicted)
density  1.26±0.1 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  DMSO: ≥15
form  powder
color  white to tan
optical activity [α]/D -180 to -195°, c = 1 in methanol
Safety Information
Hazard Codes  T
Risk Statements  60
Safety Statements  36/37
WGK Germany  3
RTECS  WH1299000
HS Code  2937230000

Drospirenone Usage And Synthesis
Natural progesterone Drospirenone is the only progesterone that has the characteristics similar to the natural progesterone currently, its structure is more like that of the natural progesterone compare with the structure of the progesterone contained in the traditional oral contraceptives.
Except the effect of anti-androgen, drospirenone has the role of anti-mineralocorticoid which can prevent water and sodium retain in the body. Not only it has the a great effectivenes of contraception, there are also many good impacts on women's health like reducing the acne, making the skin more smooth and controling the weight efficaciously.
Information on the use of oral contraceptives, drospirenone, side effects and other information edited by Chemicalbook maggie.
Side effects of human estrogen Drospirenone is a new synthetic progestin designed to mimic the effects of progesterone, it is the preogesterone which the pharmacological properties is closet to that of the natural progesterone, its also has the advantages of both salt corticosteroids and anti-androgen.
As a birth control hormones， Its can reduce the risk of pregnency by imitating progesterone, and increasing the levels of hormones. Therefore drospirenone is promoted as an effective contraception. However, since it has entered the market, drospirenone displays a negative impact on the female estrogen. When two hormones are mixed together, it would bring some bad influence to people.