716-61-0 D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL

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Product Name: D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL
Synonyms: D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL;D(-)THREO-1-(4-NITRO-PHENYL)-2-AMINO-1,3-PROPANEDIOL;CHLORAMPHENICOL-WATER SOLUBLE;(1R,2R)-2-AMINO-1-(4-NITROPHENOL)PROPANE-1,3-DIOL;(1R,2R)-(-)-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL;(1R,2R)-2-AMINO-1-(4-NITROPHENYL)PROPANE-1,3-DIOL;D-(-)threo-2-amino-1-(p-nitrophenyl)propane-1,3-diol;CHLORAMPHENICOL BASE CRYSTALLINE
CAS: 716-61-0
MF: C9H12N2O4
MW: 212.2
EINECS: 211-938-7
Product Categories: Amino Alcohols (Chiral);Chiral Building Blocks;for Resolution of Acids;Optical Resolution;Synthetic Organic Chemistry;Antibiotics;Cell Culture;Reagents and Supplements
Mol File: 716-61-0.mol

D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL Chemical Properties
Melting point  163-165 °C(lit.)
Boiling point  352.03°C (rough estimate)
density  1.3136 (rough estimate)
refractive index  -30.5 ° (C=1, 6mol/L HCl)
storage temp.  −20°C
form  Powder
pka 10.98±0.45(Predicted)
color  Light yellow
optical activity [α]25/D 30°, c = 1 in 6 M HCl
InChIKey OCYJXSUPZMNXEN-RKDXNWHRSA-N
Safety Information
Hazard Codes  Xn,T
Risk Statements  22-36/37/38-45
Safety Statements  26-45-53-22
RIDADR  UN 3259 8/PG 3
WGK Germany  3
RTECS  TY3100000
HS Code  29221990

D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL Usage And Synthesis
Chemical Properties light yellow powder
Uses D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol is an impurity of Chloramphenicol (C325030), a broad spectrum antibiotic agent obtained from cultures of the soil bacterium Streptomyces venezuel ae.
Uses Chloramphenicol base is the parent 4-nitrophenylpropylamine formed by the hydrolysis of the dichloroacetamide of chloramphenicol and is a degradation product commonly encountered with commercial production of chloramphenicol. Chloramphenicol base has no antibiotic activity but has played an integral role in the synthesis and SAR of new generation antibiotics, notably thiamphenicol and experimental analogues, bromamphenicol and methamphenicol.