Tetracycline Hydrochloride distributor

product Name

Tetracycline Hydrochloride

Synonyms

[4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide hydrochloride; Tetracycline hcl; (2Z,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione hydrochloride; (2E,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione hydrochloride; 4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride (1:1)

Molecular Formula

C₂₂H₂₅ClN₂O₈

Molecular Weight

480.8955

InChI

InChI=1/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H

CAS Registry Number

64-75-5;1170-81-6

EINECS

200-593-8

Molecular Structure

Melting point

223℃

Boiling point

799.4°C at 760 mmHg

Flash point

437.3°C

Water solubility

50 g/L

Vapour Pressur

5.82E-27mmHg at 25°C

Hazard Symbols

 Xi:Irritant;

Risk Codes

R36/37/38:;

Safety Description

S26:;
S36:;

ITEM

STANDARD

RESULTS

Appearance

Yellow, crystalline powder

Yellow crystalline powder

Solubility

Soluble in water, slightly soluble in ethanol(96 per cent), practically insoluble in acetone. It dissolves in solutions of alkali hydroxides and carbonates. Solutions in water become turbid on standing, owing to the precipitation of tetracycline.

Conforms

Identification

A. Thin-layer chromatography

B. Correspond with the standards

Conforms

C. Gives reaction of chlorides

Conforms

Specific Optical Rotation

-240°~ -255°(dried substance)

-246°

pH

1.8 ~ 2.8

2.1

Related substance

Impurity A: Not more than 3.0%

1.7%

Impurity B: Not more than 1.5%

1.0%

Impurity C: Not more than 0.5%

0.23%

Impurity D: Not more than 0.5%

0.31%

Heavy metals

Maximum 50ppm

20ppm

Loss on drying

Maximum 2.0%

1.2

Sulphated ash

Maximum 0.5%

0.15

Bacterial endotoxins

Less than 0.5IU/mg

0.32IU/mg

Assay

95.0%~ 102.0%

99%