G-STROPHANTHIN 630-60-4 C29H44O12
G-STROPHANTHIN Basic information |
Product Name: | G-STROPHANTHIN |
Synonyms: | QUABAIN;PUROSTROPHAN;STROPHANTHIN, G-;OUABAIN;(1beta,3beta,5beta,11alpha)-ahydroxy;(1beta,3beta,5beta,11alpha)-hydroxy;3-((6-deoxy-alpha-l-mannopyranosyl)oxy)-1,5,11alpha,14,19-pentahydroxycard-20(;3-[(6-deoxy-.alpha.-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-,(1.beta.,3.beta.,5.beta.,11.aCard-20(22)-enolide |
CAS: | 630-60-4 |
MF: | C29H44O12 |
MW: | 584.65 |
EINECS: | 211-139-3 |
Product Categories: | Biochemistry;Glycosides;Rhamnose;Steroidglycosides;Steroids;Sugars;Inhibitors |
Mol File: | 630-60-4.mol |
G-STROPHANTHIN Chemical Properties |
refractive index | -32 ° (C=1, H2O) |
storage temp. | Desiccate at -20°C |
solubility | H2O: 10 mg/mL cold |
form | powder |
color | white |
Merck | 6901 |
Safety Information |
Hazard Codes | T |
Risk Statements | 23/25-33 |
Safety Statements | 45 |
RIDADR | UN 1544 6.1/PG 1 |
WGK Germany | 3 |
RTECS | RN3850000 |
F | 8 |
G-STROPHANTHIN Usage And Synthesis |
General Description | Odorless, white crystals or crystalline powder as an octahydrate. Used to produce rapid digitalization in acute congestive heart failure. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter. |
Reactivity Profile | When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate) [EPA, 1998]. |
Health Hazard | G-STROPHANTHIN is classified as extremely toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for 70 kg (150-lb.) person. Exposure may result in respiratory and cardiac failure, and/or hyperalkemia. Patients with frequent premature ventricular heart beats or who have received any preparation of digitalis during preceding three weeks are prone to toxicity. |
Fire Hazard | When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate) |
Biological Activity | Selective Na + , K + -ATPase inhibitor. |
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