Colchicine

Details:

Detailed information

Colchicine is a 100% natural product, extracted from Gloriosa Superba Seeds. Colchicine has a good efficacy in treating acute gout and can quickly relieve pain and can prevent the onset of arthritis with its mechanism of action related to the inhibition of white blood cells. Our colchicine conforms with the specification of USP, with purity under HPLC not less than 98%. We are very strong in this product and has exported to countries all over the world. Please be confident with our quality. And feel free to contact us at any time. 7*24 hours service are available. 

 

Product Name: Colchicine

Synonyms:Colchineos; Colchicinum; Colchicin; Condylon; Colchicina; Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-; colchicine; Colcin; Colchisol; (-)-N-[(7S,12a5)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]-acetamide; Colchicine; (S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide; [3H]-Colchicine; Colsaloid;

CAS: 64-86-8

Molecular Formula: C22H25NO6

Molecular Weight: 399.437

Melting Point: 150-160℃

Flash Point: 392.9℃

Density: 1.32g/cm3

Reflex Index: 1.584 

Purity: ≥98.0%

Appearance: Yellowish to off-white powder

Application: used as Pharmaceutical Intermediates,Organic Intermediates,OLED 

Storage: Store in well closed container away from moisture.

Glorisa Superba

 

 

 

 

Product Name: Colchicine USP	Batch No.: BOZ/COL/17/FEB/25
Plant Part Used: Gloriosa Superba Seeds	Quantity: 20.0kgs
Manufacturing Date: Feb. 2017	Pack Size: 1.0kgs*20Packs
Retest Date: Feb.2022	Country of Origin: China

 

TEST	SPECIFICATION	RESULT
Physical Parameters
Appearance	White to yellowish white amorphous/crystalline powder.	Pale yellow crystalline powder
Solubility	Soluble in water, freely soluble in alcohol and in chloroform, slightly soluble in ether.	Complies
Identification by IR	To comply IR	Complies
Water Content	NMT 2.0% w/w	1.2% % w/w
Particle Size	95% passes through 80 mesh	98% passes through 80 mesh
Chemical Parameters
Assay (by HPLC)	94.0% to 101.0%	98.6%
Impurities
Colchiceine	NMT 0.2%	＜0.2%
Residual Solvents
Ethyl acetate	NMT 6.0%	3.5%
Dichloromethane	NMT 600 ppm	Not detected
IPA	NMT 5000 ppm	155ppm
Ethyle alcohol	NMT 5000 ppm	Not detected
Methanol	NMT 3000 ppm	185ppm
Chloroform	NMT 60 ppm	Not detected
Chromatographic purity Sum of all peaks other than colchicine peak	NMT 5.0%	1.4%
Packing - Outer: Blue colored HDPE drum.                 - Inner: one LDPE bag.
Storage - Store in well closed container away from moisture.

 

Conclusion: The above analysis results conforms with USP specification.

Note: Since it is a nature extraction, there is likely to be minor color variation from batch to batch because of the seasonal variations of the raw material. Color change will not affect the quality and efficacy of the product.