TIANFU Daunorubicin hydrochloride

Details:

Daunorubicin hydrochloride Basic information
Product Name: Daunorubicin hydrochloride
Synonyms: 5,12-Naphthacenedione,8-acetyl-10-[(3-aMino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-Methoxy-,hydrochloride (1:1), (8S,10S)-;5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride (1:1), (8S,10S)-;Daunorubicin hydrochloride, >=98%;Daunorubicin HCI;Daunorubicin Hydrochloride 98.9%;WP900 HYDROCHLORIDE;daunoblastin;daunoblastina
CAS: 23541-50-6
MF: C27H30ClNO10
MW: 563.98
EINECS: 245-723-4
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Antitumour;Carbohydrates & Derivatives;Chiral Reagents;Heterocycles;API;Anti-cancer&immunity
Mol File: 23541-50-6.mol
Daunorubicin hydrochloride Structure
Daunorubicin hydrochloride Chemical Properties
Melting point  190°C (dec)
alpha  D20 +248 ±5° (c = 0.05-0.1 in methanol)
storage temp.  −20°C
form  solid
color  red to deep red
Sensitive  Hygroscopic
Merck  13,2852
Stability: Stability
EPA Substance Registry System 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3, 6-trideoxy-.alpha.-L-lyxo- hexopyranosyl)oxy]-7,8,9, 10-tetrahydro-6,8,11-trihydroxy- 1-methoxy-, hydrochloride, (8S,10S)-(23541-50-6)
Safety Information
Hazard Codes  Xn,Xi
Risk Statements  22-40-42/43-36/37/38-20/21/22
Safety Statements  22-36/37-45-37/39-36-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  HB7878000
F  3-10
HazardClass  6.1(b)
PackingGroup  III

Daunorubicin hydrochloride Usage And Synthesis
Chemical Properties Dark Red Crystals
Uses Antineoplastic;DNA intercaling
Uses anti-neoplastic LD50 in mice 26 mg/kg
Uses A DNA intercalator which may suppress acute leukemia proliferation
Uses Anthracycline antibiotic related to the rhodomycins. Antineoplastic
General Description Orange-red powder. Thin red needles decomposing at 188-190°C. An anti-cancer drug.
Air & Water Reactions Water soluble.
Reactivity Profile Daunorubicin hydrochloride may emit toxic oxides of nitrogen when heated.
Biological Activity Anticancer agent that is clinically used to treat nonlymphocytic leukaemia. Inhibits RNA and DNA synthesis and causes DNA fragmentation in vivo .