Dofetilide high purity Dofetilide factory supply Dofetilide
Product Name: | Dofetilide |
Synonyms: | Tikosyn;Tikosyn:UK-68798;beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide;Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl) phenyl);Tikosym;Methyl[2-[4-(methylsulfonylamino)phenoxy]ethyl][4-(methylsulfonylamino)phenethyl]amine;N-[4-[2-[N-Methyl-2-(4-methylsulfonylaminophenoxy)ethylamino]ethyl]phenyl]methanesulfonamide;U-68798 |
CAS: | 115256-11-6 |
MF: | C19H27N3O5S2 |
MW: | 441.56 |
EINECS: | |
Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Pfizer compounds;Inhibitors;Active Pharmaceutical Ingredients;Medicine intermediate;Antiarrhythmic |
Mol File: | 115256-11-6.mol |
Dofetilide Chemical Properties |
Melting point | 147-1490C |
storage temp. | Store at RT |
solubility | DMSO: >20mg/mL |
pka | 7.0, 9.0, 9.6(at 25℃) |
color | white to off-white |
CAS DataBase Reference | 115256-11-6(CAS DataBase Reference) |
Safety Information |
Hazard Codes | T,N |
Risk Statements | 61-48/22-51 |
Safety Statements | 53-22-36-57 |
MSDS Information |
Provider | Language |
---|---|
Dofetilide | English |
Dofetilide Usage And Synthesis |
Chemical Properties | White Crystalline Solid |
Uses | Potassium channel blocker |
Definition | ChEBI: A tertiary amino compound that is N-ethyl-N-methylethanamine substituted by a 4-[(methylsulfonyl)amino]phenoxy and a 4-[(methylsulfonyl)amino]phenyl group at the terminal carbon atoms respectively. It is used as an an i-arrhythmia drug. |
Biological Activity | Selective potassium channel blocker. Blocks hERG K + channels; inhibits the rapid delayed-rectifier K + current (I Kr ). Displays class III antiarrhythmic properties. |
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