226256-56-0 CINACAL...

226256-56-0 CINACALCET

226256-56-0 CINACALCET

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1 Kilogram

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  • Min.Order :1 Kilogram
  • Purity: 98.0%Min
  • Payment Terms : L/C,T/T,,MoneyGram,Other

Keywords

226256-56-0 CINACALCET 98%

Quick Details

  • Appearance:Powder
  • Application:Pharma intermediates
  • PackAge:1KG -200KG Drum with pallet
  • ProductionCapacity:30|Metric Ton|Month
  • Storage:Refrigerator
  • Transportation:by sea or by air or by courier

Superiority:

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.

Our main business covers the fields below:

1.Noble Metal Catalysts (Pt.Pd...)
2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)
3.OLED intermediates (Fluorene,Carbazole,Boric acid...)
4.Customs Synthesis


Our advantage:

1.Higest quality and good package 
2.Fast delivery 
3.Better payment term 
4.Fast response to customer  within 6 hours 
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Details:

 
CINACALCET Basic information
Mechanism
Product Name: CINACALCET
Synonyms: CINACALCET;(aR)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl)propyl]-1-napthalenemethanamine;AMG 073;(aR)-a-Methyl-N-[3-[3-(trifluoromethyl)phenyl)propyl]-1-napthalenemethanamine;N-((1R)-1-(1-Naphthyl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine;364782-34-3 (Hydrochloride);Cinacalcet [inn];Hsdb 7318
CAS: 226256-56-0
MF: C22H22F3N
MW: 357.41
EINECS:  
Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Mimpara, Sensipar
Mol File: 226256-56-0.mol
CINACALCET Structure
 
CINACALCET Chemical Properties
storage temp.  Refrigerator
CAS DataBase Reference 226256-56-0(CAS DataBase Reference)
 
Safety Information
Hazardous Substances Data 226256-56-0(Hazardous Substances Data)
MSDS Information
 
 
CINACALCET Usage And Synthesis
Mechanism Cinacalcet is a basic single-chain peptide hormone secreted by the parathyroid chief cells , called PTH, it is a blend of 84 amino acids,it has an effect of elevating serum calcium and lowing phosphorus, regulating calcium and phosphorus metabolism balance of vertebrate body . In parathyroid cells,the first main precursor of PTH is synthesized at first, it is called Prepro-parathyroid, containing 115 amino acids, the predecessor of the substance after cell lysis in the thyroid becomes the second precursor substance,it is called parathyroid-hormone containing 90 amino acids , the latter becomes polypeptide containing 84 amino acids by cleaving within the cell, that is PTH. Normal human plasma PTH concentration is about 1 ng/ml. 
The main physiological function of parathyroid hormone is promoting osteolysis, bone calcium mobilization into the blood, increasing calcium, increasing vigor of serum and bone alkaline phosphatase ;it can inhibit renal tubular reabsorption of phosphate, promote urinary excretion of phosphorus , decrease phosphorus; PTH via activation of vitamin D3, indirectly promotes intestinal absorption of calcium, magnesium and phosphorus. PTH secretion is mainly affected by the regulation of calcium concentration. Blood Ca2 + elevates, PTH secretion reduces; blood Ca2 + decreases, secretion is increased. In addition, phosphorus increasing via reducing calcium stimulates the secretion of PTH, calcitonin massive release can also promote increasing secretion of PTH. 
Serum parathyroid hormone except for the study of parathyroid disease, has a certain value on the differential diagnosis of hypercalcemia and hypocalcemia The main clinical significance is as follows: 
1. Diagnosis of parathyroid disease. When there are hyperparathyroidism or ectopic PTH secretion disorder, PTH increases ; when there are hypoparathyroidism, parathyroid surgery or radiation damage, etc., PTH decreases.
2. Identification of hypercalcemia and hypocalcemia. When abnormal calcium is caused by calcium parathyroid disorders ,serum calcium lifts as serum PTH lifts, while abnormal blood calcium is caused by other causes , PTH does not change.
The above information is edited by the Chemicalbook of Tian Ye.
Chemical Properties Yellow Oil
Uses Cinacalcet is the first calcimimetic drug approved by the United States Food and Drug Administration for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease
Uses macular degeneration therapy
Uses Labeled Cinacalcet, intended for use as an internal standard for the quantification of Cinacalcet by GC- or LC-mass spectrometry.
Definition ChEBI: A secondary amino compound that is (1R)-1-(naphthalen-1-yl)ethanamine in which one of the hydrogens attached to the nitrogen is substituted by a 3-[3-(trifluoromethyl)phenyl]propyl group.
 
CINACALCET Preparation Products And Raw materials

 

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