Aniracetam 99% CAS ...

Aniracetam 99% CAS 72432-10-1
Aniracetam 99% CAS 72432-10-1
Aniracetam 99% CAS 72432-10-1

Aniracetam 99% CAS 72432-10-1

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  • Purity: 99%
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Keywords

aniracetam 72432-10-1 aniracetam 99%

Quick Details

  • Appearance:White crystalline powder
  • Application:CAS 521-18-6 Stanolone powder 99% pharmaceutical industry
  • PackAge:(1). 1-10kg / foil bag (2). 25kg / drum (3). 1-50kg / barrel (4). By request of clients
  • ProductionCapacity:1000|Kilogram|Month
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Aniracetam Basic information
Levetiracetam class brain cell metabolism drugs Pharmacological effects Pharmacokinetics Side effects Precautions Chemical Properties Uses Production methods
Product Name: Aniracetam
Synonyms: 1-(4-methoxybenzoyl)-2-pyrrolidinon;1-(p-methoxybenzoyl)-2-pyrrolidinon;1-p-anisoyl-2-pyrrolidinone;draganon;sarpul;1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE;ANIRACETAM;RO 13-5057
CAS: 72432-10-1
MF: C12H13NO3
MW: 219.24
EINECS: 1308068-626-2
Product Categories: Glutamate;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Smart drug;Nootropic;pharmaceutical intermediate
Mol File: 72432-10-1.mol
Aniracetam Structure
 
Aniracetam Chemical Properties
Melting point  121-122 C
storage temp.  Store at RT
Water Solubility  Soluble in chloroform. Also soluble in ethanol. Insoluble in water
Merck  14,662
CAS DataBase Reference 72432-10-1(CAS DataBase Reference)
 
Safety Information
WGK Germany  2
RTECS  UY5781900

 

Aniracetam Usage And Synthesis

 

 

Levetiracetam class brain cell metabolism drugs

Aniracetam, also known as aniracetam, together with piracetam and nefiracetam, belong to the same class of piracetam metabolized drugs of brain cells. These drugs can enhance the activity of synaptic neurons phospholipase, increase the ATP formation and transport in brain, increase protein synthesis and RNA, promote the usage of brain on amino acids, phospholipids, glucose and oxygen, increase the patient's response, excitability and memory. Aniracetam has a higher effect than piracetam, but with a relatively minor side effect.

Pharmacological effects

Aniracetam, a cyclized derivative of γ-aminobutyric acid, can improve the brain function. It can selectively exert effect on central nervous system through penetration into blood-brain barrier. It can activate the metabolism activity of brain cell and protect the nerve cells. This product can also promote the intelligence by affecting the glutamate receptor system. Moreover, it improves skin’s resistance to hypoxia, preventing the occurrence of malfunction of learning and memory caused by a variety of chemical substances, hypercapnia, scopolamine and electrical shock. This product has no sedative or excitation effect. Animal experiments show that this product promotes the memory recovery in normal rats’ learning process. It can fight against hypoxia-induced memory recession and relieve the memory malfunction caused by certain reasons.
[Indications] It is used for the treatment of mild or moderate malfunction of learning, memory and cognition in vascular dementia and Alzheimer's disease. It can also be used for treating memory recession after stroke, memory defect in old people and children who undergo development retardation.
.

Pharmacokinetics

According to literature, it is rapidly absorbed after oral administration by rats. The plasma concentration reaches highest level within 20 to 40 minutes. The drug is mainly distributed in the gastrointestinal tract, kidney, liver, brain and blood. After 24 hours, 77% to 85% is excreted out through urine, 4% from faeces. Major metabolite in urine is N-p-anisoyl-aminobutyric acid and 5-hydroxy-2-pyrrolidone.
Human: After oral administration, half-life of blood Plains drug elimination averages at 20 to 30 minutes. Plasma concentration becomes undetectable after two hours.

Side effects

This product has fewer adverse reactions, occasionally dry mouth, anorexia, constipation, dizziness, and drowsiness. They disappear after stopping taking the drug.

Precautions

1. Adjust the dose for patients of liver dysfunction. 
2. It can deteriorate the symptoms of Huntington's chorea.
3. Patients who is allergic to this drug or other pyrrolidone-class drugs are not allowed.
4. Safety range: 0.3~1.8g/d.

Chemical Properties

Crystallization from ethanol, m.p. 12l~122 °C. Acute toxicity LD50 for rat, mouse (mg/kg): 4500,> 5000 oral.

Uses

1. Piracetam derivative, a improvement agent for γ-lactam brain function. Selectively exert effect on the brain system, promote and enhance memory function. Compared with Piracetam, it has a stronger effect, faster onset of action, and lower toxicity. Used for improving brain function, especially treating the behavioral and mental disorders for sequela patients of senile dementia, cerebrovascular disease. 
2. It is a γ-lactam-class agent of improving brain function. It can exert on the brain tissue through penetrating the blood-brain barrier, and improve brain function and memory.

Production methods

Method 1: Reflux the reaction mixture of 2-pyrrolidone and methoxy benzoyl chloride at 0~10 °C in ether and in the presence of triethylamine for three hours to get the Aniracetam. 
Method 2: Perform the reaction between p-methoxy benzoic acid and thionyl chloride to get the methoxy benzoyl chloride (yield 90%). Then perform the reaction between methoxybenzoyl chloride and 4-aminobutyric acid in an aqueous solution of sodium hydroxide and in the presence of benzyl triethyl ammonium salt (of TEBA) to get 4-(4-methoxybenzoyl) amino butyric acid (yield 69.4%). Then have cyclization reaction in the presence of toluene and thionyl chloride to get aniracetam, yield 80.4%, mp 118~120 °C.
Method 3: Methoxybenzoic acid is chloridized as post-methoxy benzoyl chloride first. Then it is reacted together with Sodium 2-pyrrolidone in tetrahydrofuran and 4-dimethylaminopyridine (DMAP) to obtain the aniracetam yield 76.2% (Take account of p-methoxy benzoyl chloride), the melting point of 118~119 °C.
Method 4: 2-pyrrolidone was refluxed 1 hour in toluene containing sodium methoxide first. Then methanol was totally evaporated. Add TEBA at 10 °C, Titrate a toluene solution of p-anisoyl chloride and stir them at room temperature for 0.5h. Then stirred at 50 °C for 6h to obtain the aniracetam of 85% yield (take account of 2-pyrrolidone), melting point 120~121 °C.
Method 5: 2-pyrrolidinone and triethylamine is mixed at 0~10 °C first. Then perform titration of chlorotrimethylsilane for 2 h reaction at room temperature. Add the dioxane solution of Methoxybenzoyl chloride and stir 2h at 40 °C to obtain aniracetam, yield 65%.

Chemical Properties

Crystalline Solid

Uses

cognitive enhancer

Uses

Cognition enhancer related to Piracetam. Nootropic.

Biological Activity

Nootropic, with modulatory actions through allosteric potentiation of AMPA specific receptors, reduction of glutamate receptor desensitization and potentiation of metabotropic glutamate receptor activity. Anxiolytic following systemic administration.

 

Binbo Biological Co. Ltd., is a professional high-tech enterprise which engaged in Biological products raw materials. Binbo is engaged in R&D with perfect equipments and advanced detecting instruments. The factory is in strict accordance with GMP standard in the course of design and construction.

Details:

Aniracetam 99% CAS 72432-10-1

Aniracetam is a synthetic compound, one of the hydroxyphenylacetamide heterocyclic compounds, which is a brain function enhancer and neuroprotective agent.  , known for its ability to improve memory, concentration, and overall cognitive function. Developed in the 1970s, Aniracetam quickly became popular due to its unique properties. It is believed to enhance communication between neurons in the brain, thereby improving cognitive processes. It works primarily on parts of brain cells (neurons) called AMPA receptors.  AMPA receptors help signals move quickly between neurons, which can improve memory, learning, and anxiety. The exact mechanism of action of Aniracetam is that it acts on various neurotransmitter receptors in the brain, such as acetylcholine and dopamine receptors. By modulating these receptors, Aniracetam is thought to increase the release and availability of neurotransmitters, thereby improving cognitive function.

 

 

1. Adjust the dose for patients of liver dysfunction. 
2. It can deteriorate the symptoms of Huntington's chorea.
3. Patients who is allergic to this drug or other pyrrolidone-class drugs are not allowed.
4. Safety range: 0.3~1.8g/d.

 

 

Aniracetam is a safe and effective brain function enhancer and neuroprotectant that has significant effects on improving memory, learning ability and depressive symptoms. Multiple studies have shown that Aniracetam can enhance short-term and long-term memory formation, which is useful for individuals looking to improve their learning abilities. Another interesting aspect of Aniracetam is its potential to enhance creativity. Many users report an increase in divergent thinking, improved problem-solving skills, and smoother flow of ideas. This may be beneficial for individuals in creative careers or anyone seeking to tap into their creative potential.

 

 


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Binbo Biological Co., Ltd. is located in the convenient transportation and beautiful scenery of Jining high-technology industrial zone - Jinxiang economic Development Zone. There is a 105 National road links north and south when Zaocao and Dongfeng Roads connect east and west. Besides, provincial expressway and Ji-Xu expressway which connect Beijing,Shanghai,Fuzhou, and several cities across the JinXiang economic development zone. More importantly, there are only 20 km to Jining airport and close to Qufu high-speed railway station.These convenient geographical conditions bring the development opportunities for this economic development zone.

Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products raw materials. Company was established in 2001, currently our company has more than 28 thousand square meters covering area. Factory buildings and workshops were establishsd by modern production requirements.There are three steps of development project which planned to invest around 60 million RMB. Currently the first step were finished and spent 28 million RMB, which met the production and office requirements.

Binbo is engaged in R&D with perfect equipments and advanced detecting instruments. The factory is in strict accordance with GMP standard in the course of design and construction.

 

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