63775-96-2 CYCLOSP...

63775-96-2 CYCLOSPORIN D C63H111N11O12

63775-96-2 CYCLOSPORIN D C63H111N11O12

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CYCLOSPORIN D 63775-96-2 C63H111N11O12

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CYCLOSPORIN D Basic information
Product Name: CYCLOSPORIN D
Synonyms: CYCLOSPORIN D;Val2-cyclosporine;(3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Val-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-);(3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]cyclo(L-Leu-L-Val-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-);Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl];7-L-Valinecyclosporin A;Cyclosporine IMpurity-D;7-L-valinecyclosporine A
CAS: 63775-96-2
MF: C63H111N11O12
MW: 1214.62
EINECS: 200-835-2
Product Categories: ACTIVE PHARMACEUTICAL INGREDIENTS;Intermediates & Fine Chemicals;Peptides;Pharmaceuticals;Anti-cancer&immunity
Mol File: 63775-96-2.mol
CYCLOSPORIN D Structure
 
CYCLOSPORIN D Chemical Properties
Melting point  148-1510C
alpha  D20 -245° (c = 0.52 in CHCl3); D20 -211° (c = 0.51 in methanol)
Fp  9 °C
storage temp.  -20°C Freezer
 
Safety Information
Hazard Codes  F,Xn,T
Risk Statements  11-20/21/22-36-39/23/24/25-23/24/25
Safety Statements  16-36/37-45-7
RIDADR  UN 1648 3 / PGII
MSDS Information
 
 
CYCLOSPORIN D Usage And Synthesis
Chemical Properties Colorless Crystalline Solid
Uses A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
Uses Cyclosporin D is a minor analogue of the cyclosporin family which is only weakly immunologically active. Cyclosporin D is a potent inhibitor of tumour-promoting phorbol esters on mouse skin in vivo, and a potent inhibitor of calcium/calmodulin-dependent EF-2 phosphorylation in vitro.
Uses Cyclosporin D is a minor analogue of the cyclosporin family which is only weakly immunologically active. Cyclosporin D is a potent inhibitor of tumor-promoting phorbol esters on mouse skin in vivo, and a potent inhibitor of calcium/calmodulin-dependent EF-2 phosphorylation in vitro.
 
CYCLOSPORIN D Preparation Products And Raw materials

 

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