Saxagliptin

Saxagliptin
Saxagliptin
Saxagliptin
Saxagliptin
Saxagliptin

Saxagliptin

Min.Order / FOB Price:Get Latest Price

1 Gram

FOB Price:USD 10.0000 -12.0000

  • Min.Order :1 Gram
  • Purity: 98%
  • Payment Terms : L/C,D/A,D/P,T/T,

Keywords

361442-04-8 Lipid regulating drugs Pharmaceuticals

Quick Details

  • Appearance:White Powder
  • Application:Health Proctect
  • PackAge: according to customers' requirements
  • ProductionCapacity:100|Kilogram|Month
  • Storage:2 Years
  • Transportation:International express delivery

Superiority:

Details:

 

Product name

Saxagliptin                          CAS:361442-04-8        

Packaging, Storage &Shelf Life

Package

1kg/bag,25kg/ drum

Storage

Stored in original packaging for two years at a temperature not exceeding 40°C.
Shelf life

2 years if sealed and stored properly.

Specification

Test

Specifications

Result

Assay  Content % by HPLC

Min.98%

99.08%

Appearance

white powder

Complies

Odor

Characteristic

Complies

PH

5.0-7.0

6.09

Clarity of water solution

Transparent, colorless, none suspended matters

Complies

Loss on drying %

MAX 0.5

0.25

Ash %

MAX.0.5

0.38

Melting point

+202.0-212.0°C

Complies

Specific rotation

+174.0-+186.0

+181.0

Hydroquinone

Negative

Complies

Heavy metals PPM

MAX.10

Complies

As          AAS

Pb

Cd

<2ppm

<1ppm

<1ppm

Complies

Complies

Complies

Microbiology

Total Plate Count

Yeast & Mold

E.Coli

S. Aureus

Salmonella

 

<1000cfu/g

<100cfu/g

Negative

Negative

Negative

 

122 cfu/g

13 cfu/g

Complies

Complies

Complies

Conclusion

Conform with specification

 
 
Mechanism of Action:
Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor antidiabetic for the treatment of type 2 diabetes. DPP-4 inhibitors are a class of compounds that work by affecting the action of natural hormones in the body called incretins. Incretins decrease blood sugar by increasing consumption of sugar by the body, mainly through increasing insulin production in the pancreas, and by reducing production of sugar by the liver. [Bristol-Myers Squibb Press Release] DPP-4 is a membrane associated peptidase which is found in many tissues, lymphocytes and plasma. DPP-4 has two main mechanisms of action, an enzymatic function and another mechanism where DPP-4 binds adenosine deaminase, which conveys intracellular signals via dimerization when activated. Saxagliptin forms a reversible, histidine-assisted covalent bond between its nitrile group and the S630 hydroxyl oxygen on DPP-4. The inhibition of DPP-4 increases levels active of glucagon like peptide 1 (GLP-1), which inhibits glucagon production from pancreatic alpha cells and increases production of insulin from pancreatic beta cells.
 
 
 
 All Key Manufacturers and Suppliers of Baoji Guokang have routine inspections to ensure they are in compliance with the standards set in place during the original Supplier Assessment Inspection.
 
Production Inspection Process:
Our Group service includes regular and thorough inspections throughout the manufacturing process, eliminating the need to employ additional quality control inspectors.
- Raw material before any production begins
- Pre-production samples to ensure specifications are being met
- In-process to confirm that standards are maintained
- Pre-shipping to ensure that the product arrives to the customer exactly as expected and is packaged
correctly to prevent any damage in transit.

 We can help operating split shipments, meeting the factory minimum quantity but ship them in 2 or 3 shipments with required gaps among. This allows you to move stock through your business without taking up space and capital.
We will arrange the subsequent shipments from our factory to your warehouse.
We can consolidate your small orders from multiple factories, delivering all at the same time to you or your customers,using the most cost-effective route available. At the time of order placement, we will offer details to you about the volume of each component part and what size container will be used.
  We can offer the complete package from concept to delivery; arranging everything up until products arrive at your own door or distribution hub.
   Delivery can be offered.
    - Utilizing your own freight-forwarder
    - FOB to a port in China
    - CIF to a port near you
   Whether you have your own freight-forwarder or you would like to organize shipment; whether you require delivery FOB in China or CIF to a port near you, we are glad to quote and supply whichever way you choose. Please feel free to discuss all options with us.

 

1.Client is first.We are trying to bring maximum profit to our clients and we only share small.
2.Credibility is the most important.
3.Quality control is our life.
4.Great sense of responsibility.
We will be responsible for not only our products, our clients, our suppliers, also the society.

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