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2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide, monohydrate Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester m 2h-1,3,2-oxazaphosphorine,tetrahydro-2-(bis(2-chloroethyl)amino)-,2-oxide,mo -2monohydrate
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Chemical Properties | White to Off-White Solid |
Uses | It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen. |
Uses | antineoplastic, alkylating agent |
Uses | alkylating agent in cancer therapy |
Uses | An immunosuppressive, cytotoxic apoptosis inducer. |
Definition | ChEBI: The monohydrate of cyclophosphamide. |
Brand name | Cytoxan (Bristol-Myers Squibb); Neosar (Sicor). |
General Description | Fine white crystalline powder with a slightly bitter taste. Little or no odor. |
Air & Water Reactions | Water soluble. Sensitive to moisture and light. Aqueous solutions may be kept for a few hours above room temperature, but hydrolysis occurs at temperatures above 86°F. Cyclophosphamide monohydrate undergoes both specific acid and specific base catalysis at extreme pHs. Spontaneous hydrolysis in aqueous solutions. |
Reactivity Profile | Polymerization can occur at temperatures > 120° F. Cyclophosphamide monohydrate reacts with strong oxidizing agents, strong acids and strong bases. Benzyl alcohol increases rate of hydrolysis. |
Fire Hazard | Cyclophosphamide monohydrate is probably combustible. |
Safety Profile | Confirmed human carcinogen. Poison by ingestion and intravenous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl-, PO,, and NOx. |
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