CasNo.80-08-0,Hot Sale 80-08-0 80-08-0 Good Supplier In China 80-08-0 4,4'-Diaminodiphenylsulfone,(80-08-0) Suppliers

1 Kilogram	FOB Price: USD 10.0000

Min.Order :1 Kilogram
Purity: 99%min
Payment Terms : T/T,,MoneyGram

Keywords

Hot Sale 80-08-0 80-08-0 Good Supplier In China 80-08-0 4,4'-Diaminodiphenylsulfone

Quick Details

Appearance:white crystalline powder
Application:reaserch,pharmaceutical raw material
PackAge:1kg/pack,25kg/drum
ProductionCapacity:100000|Kilogram|Year
Storage:Store in dry、dark、ventilated place.
Transportation:BY EMS,DHL,Fedex,UPS

Superiority:

Hot Sale 80-08-0 Good Supplier In China 4,4'-Diaminodiphenylsulfone

Dapsone is an anti-inflammatory, antimalarial, and antibacterial compound. In vivo, dapsone (34 μg/animal per day) reduces epidermal hyperproliferation and epithelial thickness in the esophagus in a mouse model of proliferative dermatitis. It reduces lipid peroxidation, myeloperoxidase activity, and cellular apoptosis in the striatum of rats following ischemia and reperfusion injury. Dapsone reduces growth of M. leprae in the footpad of mice (MIC = 0.01-0.03 μg/ml in sera) and induces clearance of P. knowlesi infections in macaques.It also reduces the number of P. gallinaceum sporozoites in a mosquito population allowed to feed on dapsone-treated chicks. Formulations containing dapsone have been used in the treatment of malaria, acne, dermatitis, and leprosy.

It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy. It is a second-line medication for the treatment and prevention of Pneumocystis pneumonia and for the prevention of toxoplasmosis in those who have poor immune function. Additionally, it has been used for acne as well as other skin conditions. Moreover it is employed as an anti-inflammatory drug, anti-infective drug, a leprostatic drug and an antimalarial drug.

Details:

Dapsone is a synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration.

Product Number	D0089
Purity / Analysis Method	>98.0%(T)(HPLC)
Molecular Formula / Molecular Weight	C₁₂H₁₂N₂O₂S = 248.30
Physical State (20 deg.C)	Solid
CAS RN	80-08-0
Reaxys Registry Number	788055
PubChem Substance ID	87566830
SDBS (AIST Spectral DB)	7075
Merck Index (14)	2822
MDL Number	MFCD00007887