Nadifloxacin

Nadifloxacin

Nadifloxacin

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1 Gram

Negotiable

  • Min.Order :1 Gram
  • Purity: 99% purity
  • Payment Terms : T/T,Other

Keywords

NDFX 124858-35-1 99% purity

Quick Details

  • Appearance:White to yellow crystalline solid
  • Application:API
  • PackAge:According to the need to packing
  • ProductionCapacity:100|Kilogram|Month
  • Storage:sealed,dry,low temperature
  • Transportation:air,sea and courier

Superiority:

Nadifloxacin Basic information

Abstract Acne Treatment Antibacterial Activity Pharmacokinetics Drug resistance Application References
Product Name:    Nadifloxacin
Synonyms:    NDFX;Nadifiloxacin;NadifloxacinAPI;7-fluoro-8-(4-hydroxypiperidin-1-yl)-12-Methyl-4-oxo-1-azatricyclo[7.3.1.0^{5,13}]trideca-2,5(13),6,8-tetraene-3-carboxylic acid;9-Fluoro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid;NADIFLOXACIN;9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic Acid;Acuati
CAS:    124858-35-1
MF:    C19H21FN2O4
MW:    360.38
EINECS:    638-863-6
Product Categories:    ACUATIM;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:    124858-35-1.mol

Details:

Nadifloxacin Chemical Properties
Melting point     245-2470C (dec)
Boiling point     624.9±55.0 °C(Predicted)
density     1.46±0.1 g/cm3(Predicted)
storage temp.     Sealed in dry,Store in freezer, under -20°C
pka    5.55±0.40(Predicted)
form     White to yellow crystalline solid.
Merck     14,6345
CAS DataBase Reference    124858-35-1(CAS DataBase Reference)
Safety Information
Toxicity    LD50 male, female mice and rats (mg/kg): 376.5, 420.6, 225.7, 240.5 i.v. (Hashimoto)

Chemical Properties    Off-White Crystalline Solid
Originator    Otsuka (Japan)
Uses    Fluorinated quinolone antibacterial (topical).
Uses    Fluorinated quinolone antibacterial (topical)
Uses    Calcium salt of polyacrylic acid crosslinked with divinyl glycol
Brand name    Acuatim
Pharmaceutical Applications    A lipophilic tricyclic fluorobenzoquinoline with a 4- hydroxylpiperinyl moiety at the C-8 position, formulated as a cream for topical use. It is active against many Grampositive bacteria involved in skin infections, including Propionibacterium acnes (MIC 0.25–2.0 mg/L), and Staph. aureus (MIC 0.015–2 mg/L). It appears to inhibit the generation of reactive oxygen species by neutrophils. The sodium salt is used as a 1% cream for use in acne vulgaris and cutaneous staphylococcal infections.

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