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Dasatinib Monohydrate 863127-77-9 C22H28ClN7O3S
Introduction | dasatinib, also known as DASA tin IB, is a gray-white to yellow solid chemical. Dasatinib is an antineoplastic drug, which is mainly used to treat imatinib mesylate-resistant or intolerant Philadelphia chromosome positive (Ph) chronic myeloid leukemia (CML) in chronic phase, accelerated phase and blast phase (acute granulosis and acute leaching) in adult patients. |
Use | dasatinib for already treated, including Imatinib mesylate/Gleevec resistant or intolerant chronic myelogenous leukemia in all phases (chronic phase, accelerated phase, lymphoid cell blast phase and myeloid cell blast phase) in adult patients. At the same time, the FDA has approved dasatinib for the treatment of Philadelphia chromosome-positive adult patients with acute lymphoblastic leukemia who are resistant or intolerant to other therapies. anticancer drug Intermediate/pharmaceutical intermediate |
biological activity | Dasatinib Monohydrate (BMS-354825) is a new and effective multi-target inhibitor, src and c-Kit,IC50 <1 nM,0.8 nM and 79 nM, respectively. |
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