Phenoxyethanol 204-589-7 pharmaceutical intermediates raw material
Phenoxyethanol is a preservative used in consumer and health care products, including vaccines, pen inks, ear drops, shampoos, skin cleansers, moisturizers, sun care products, and topical medicaments. The preservative Euxyl-K 400 also contains 2-phenoxyethanol, in combination with methyldibromoglutaronitrile.
Phenoxyethanol is commonly used in cosmetics for its antibacterial and antifungal properties. It is increasingly being used in vaccines as a substitute for thiomersal and is also a component of pen inks and, more rarely, ear drops.Reactions to phenoxyethanol have rarely been reported. Three cases of CoU induced by phenoxyethanol in cosmetics have been reported.2-Phenoxyethanol is used as a single agent and in combination with other preservatives such as 1,2-dibromo-2,4-dicyanobutane (Euxyl K 400) and parabens, or in conjunction with quaternary ammonium compounds.The possibility of immunological IgE-mediated reaction could not be confirmed because specific IgE against 2-phenoxyethanol was negative.
Product Name: | 2-Phenoxyethanol |
CAS: | 122-99-6 |
MF: | C8H10O2 |
MW: | 138.16 |
EINECS: | 204-589-7 |
Melting point | 11-13 °C (lit.) |
Boiling point | 247 °C (lit.) |
density | 1.102 g/mL at 25 °C (lit.) |
vapor density | 4.8 (vs air) |
vapor pressure | 0.01 mm Hg ( 20 °C) |
refractive index | n20/D 1.539 |
FEMA | 4620 | 2-PHENOXYETHANOL |
Fp | >230 °F |
storage temp. | Store below +30°C. |
solubility | soluble, clear, colorless to very faintly yellow |
form | Liquid |
pka | 14.36±0.10(Predicted) |
Specific Gravity | 1.109 (20/4℃) |
color | Clear colorless |
PH | 7 (10g/l, H2O, 23℃) |
Odor | Faint aromatic odor |
PH Range | 7 at 10 g/l at 23 °C |
explosive limit | 1.4-9.0%(V) |
Water Solubility | 30 g/L (20 ºC) |
Merck | 14,7257 |
BRN | 1364011 |
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