Factory high qualit...

Factory high quality Lincomycin HCl
Factory high quality Lincomycin HCl

Factory high quality Lincomycin HCl

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1 Gram

FOB Price:USD 159.0000 -170.0000

  • Min.Order :1 Gram
  • Purity: purity 98%-101%
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Keywords

Lincomycin HCl 859-18-7 Lincomycin

Quick Details

  • Appearance:white powder
  • Application:Dietary supplements;Food;Additives;Pharmaceuticals;medicines;cosmetics Heart protection
  • PackAge:1kg/bag,5kg/bag,25kg/drum
  • ProductionCapacity:1|Metric Ton|Day
  • Storage:20°
  • Transportation:20

Superiority:

Lincocin Hydrochloride

CAS: 859-18-7

Molecular Formula: C18H35ClN2O6S

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859-18-7 - Names and Identifiers

Name Lincocin Hydrochloride
Synonyms U-10149A
LINCOMYCIN HCL
Lincomycin Hcl
Lincocin Hydrochloride
LINCOCIN HYDROCHLORIDE
lincomycin hydrochloride
LINCOMYCIN HYDROCHLORIDE
lincomycin standard solution
Lincomycin hydrochloride anhydrous
N-[2-HYDROXY-1-(3,4,5-TRIHYDROXY-6-METHYLSULFANYL-OXAN-2-YL)-PROPYL]-1-METHYL-4-PROPYL-PYRROLIDINE-2-CARBOXAMIDE
methyl 6,8-dideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride
METHYL 6,8-DIDEOXY-6-(1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO)-1-THIO-D-ERYTHRO-ALPHA-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE
ALPHA-METHYL-6,8-DIDEOXY-6-[1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO]-1-THIO-D-ERYTHRO-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE
CAS 859-18-7
EINECS 212-726-7
InChI InChI=1/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14+,15-,16-,18-;/m1./s1
InChIKey POUMFISTNHIPTI-BOMBIWCESA-N

859-18-7 - Physico-chemical Properties

Molecular Formula C18H35ClN2O6S
Molar Mass 443
Melting Point 156-158C
Boling Point 646.8°C at 760 mmHg
Flash Point 345°C
Water Solubility Soluble in water.
Solubility H2O: 50mg/mL, clear, colorless
Vapor Presure 1.85E-19mmHg at 25°C
Appearance solid
Color white to white with yellow cast
BRN 4171650
Storage Condition 2-8°C
Stability Hygroscopic
MDL MFCD00058237
Use Linamycin is an antibiotic that forms cross-links in the peptide-based transferase cyclic region of 23S rRNA and inhibits bacterial protein synthesis.

859-18-7 - Risk and Safety

Risk Codes R36/37/38 - Irritating to eyes, respiratory system and skin.
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
WGK Germany 2
RTECS RH6315000
FLUKA BRAND F CODES 10
HS Code 29419000

859-18-7 - Reference

Reference 

Show more

1. He Pinjing, Guan Dongxing, Wu duo, et al. Inhibitory effect of ammonia nitrogen and lincomycin on anaerobic digestion...

859-18-7 - Reference Information

EPA chemical substance information information provided by: ofmpeb.epa.gov (external link)
Overview lincomycin hydrochloride is used for semi-synthetic preparation of clindamycin, a semi-synthetic chlorinated derivative of lincomycin, it is suitable for various infectious diseases caused by gram-positive bacteria and anaerobic bacteria, and can also be used for the treatment of infections caused by methicillin-resistant Staphylococcus aureus.
characteristics clindamycin hydrochloride is considered as one of the 20 most important antibiotics due to its strong anti-infection ability and wide therapeutic range. Structurally, lincomycin hydrochloride is modified by two parts of Lincosamide (LSM) and Propylproline (PPL). In recent years, the research on the biosynthesis mechanism of lincomycin has made substantial achievements, and the biosynthetic pathway has become increasingly clear.
antibiotics lincomycin hydrochloride also known as clindamycin hydrochloride, jiminlike, lincomycin, lincomycin, linkenamycin hydrochloride is a white crystalline powder at room temperature, with slight or special odor, bitter taste, soluble in water or methanol, and its hydrochloride form is commonly used in feed. The drug is the product of the growth of the Streptomyces Streptomyces C. Nensis flora, which is a lincoamine alkaline antibiotic, which acts on the 50s subunit of the ribosome of sensitive bacteria, prevents the extension of the peptide chain, thereby inhibiting the protein synthesis of bacterial cells, has a bacteriostatic effect, but also has a bactericidal effect on highly sensitive bacteria at high concentrations. The antibacterial spectrum is the same as that of lincomycin, but the antibacterial activity is strong, oral absorption is fast and complete (about 90%), and eating has little effect on absorption. Lincomycin hydrochloride has strong antibacterial effect on Gram-positive bacteria, some anaerobic bacteria and mildew, and its antibacterial spectrum is narrower than erythromycin. Staphylococcus aureus, hemolytic Streptococcus, Pneumonia coccus and pig Pneumonia mildew body, chicken blood mold body is sensitive to this product, but Enterococcus is generally resistant to this product; Anaerobic bacteria such as Bacteroides, tetanus bacilli, clostridium, Clostridium perfringens, digestive cocci are also sensitive to this product. Mainly used in the treatment of gram-positive bacteria, especially penicillin-resistant gram-positive bacteria caused by a variety of infections, mildew-caused poultry chronic respiratory disease, pig asthma, anaerobic infections such as chicken necrotic enteritis, etc, it is also used in the treatment of swine Treponema dysentery, toxoplasmosis and actinomycosis in dogs and cats.
The effect of lincomycin hydrochloride on septicemia caused by most Gram-negative bacteria and some anaerobic bacteria, female genital tract, endometritis, nongonococcal tubal ovarian abscess, pelvic cellulitis, postoperative vaginal adnexal infection, peritonitis, abscess, Pneumonia, lung abscess, skin and soft tissue infections have a therapeutic effect. Also used for Streptococcus and Staphylococcus caused by sepsis, bone and joint infection, chronic bone and joint infection of surgical adjuvant therapy, Staphylococcus caused by acute hematogenous osteomyelitis. But this product can not penetrate into the cerebrospinal fluid, it is not suitable for the treatment of meningitis. Topical treatment of gram-positive bacteria purulent infection.
Clinical application 1. Oral preparation is suitable for the treatment of sensitive Staphylococcus, Streptococcus, Pneumonia coccus and anaerobic bacteria caused by respiratory tract infection, abdominal infection, female reproductive tract infection, pelvic infection, skin and soft tissue infection.
2. In addition to the above-mentioned infections, injectable preparations can be used to treat serious infections caused by Streptococcus, Pneumonia coccus and Staphylococcus, such as septicemia, bone and joint infections, surgical adjuvant therapy for chronic bone and joint infections, acute Hematogenous Osteomyelitis caused by Staphylococcus.
3. Lincomycin hydrochloride can also be used for the treatment of infectious diseases that are allergic to penicillin or are not suitable for use with penicillin drugs.
tablets: 0.25g,0.5g per tablet; Injection: 0.2g,0.6g per tablet.
biological activity Lincomycin hydrochloride (NSC 70731) is a salt of Lincomycin, they are substances produced by the growth of members of the genus Streptomyces.
Use linkenamycin is an antibiotic that forms cross-links in the peptidyl transferase cyclic domain of 23S rRNA, inhibition of bacterial protein synthesis.

Details:

Lincomycin hydrochloride

Mol Download Chemical properties

CAS:

859-18-7

MF:

C18H35ClN2O6S

MW:

443

EINECS:

212-726-7

MDL No.:

MFCD00083647

Properties

Melting point:

156-158C

storage temp. 

2-8°C

solubility 

H2O: 50 mg/mL, clear, colorless

form 

solid

color 

white to white with yellow cast

Water Solubility 

Soluble in water.

BRN 

4171650

Stability:

Hygroscopic

InChIKey

POUMFISTNHIPTI-BOMBIWCESA-N

SMILES

[C@]([H])([C@]1([H])[C@@H]([C@H](O)[C@@H](O)[C@@H](SC)O1)O)([C@H](O)C)NC([C@H]1N(C[C@H](CCC)C1)C)=O.Cl |&1:0,2,4,5,7,9,14,19,22,r|

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