Top Quality Natural...

Top Quality Natural Quinine hydrochloride dihydrate
Top Quality Natural Quinine hydrochloride dihydrate
Top Quality Natural Quinine hydrochloride dihydrate
Top Quality Natural Quinine hydrochloride dihydrate

Top Quality Natural Quinine hydrochloride dihydrate

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1 Kilogram

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  • Purity: 99%
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Keywords

Quinine hydrochloride dihydrate 6119-47-7 Quinine hydrochloride

Quick Details

  • Appearance:white powder
  • Application:Pharmaceutical;Food Preservative;Cosmetics;Food
  • PackAge:1kg/bag,5kg/bag,25kg/drum
  • ProductionCapacity:5000|Kilogram|Month
  • Storage:in a cool&dry place
  • Transportation:By air,By Sea

Superiority:

Quinine monohydrochloride dihydrate

CAS: 6119-47-7

Molecular Formula: C20H27ClN2O3

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6119-47-7 - Names and Identifiers

Name Quinine monohydrochloride dihydrate
Synonyms Quinine Monohy
Quinine HCl Dihydrate
Quinine monohydrochloride dihydrate
QUININEHYDROCHLORIDE,DIHYDRATE,CRYSTAL
(9R)-6'-methoxycinchonan-1'-ium-9-ol chloride dihydrate
(8α, 9R)-6′-Methoxycinchonan-9-ol monohydrochloride dihydrate
(4beta,8alpha,9R)-6'-methoxycinchonan-9-ol hydrochloride dihydrate
Cinchonan-9-ol, 6-methoxy-, monohydrochloride, dihydrate, (8.alpha.,9R)-
(R)(6-Methoxy-4-quinolyl)(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol hydrochloride
(R)(6-methoxy-4-quinolyl)(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol monohydrochloride dihydrate
CAS 6119-47-7
EINECS 612-097-2
InChI InChI=1/C20H24N2O2.ClH.2H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;2*1H2/t13 ,14 ,19 ,20-;;;/m1.../s1
InChIKey MPQKYZPYCSTMEI-HPVDNOPASA-N

6119-47-7 - Physico-chemical Properties

Molecular Formula C20H27ClN2O3
Molar Mass 378.9
Melting Point 115-116°C (dec.)(lit.)
Boling Point 495.9°C at 760 mmHg
Specific Rotation(α) [α]D20 -245~-255° (c=2, dil. HCl) (After Drying)
Flash Point 122 °C
Water Solubility Sparingly soluble in water.(0.26 g/L) (25°C),
Solubility H2O: soluble0.25/5g/mL, clear, colorless
Vapor Presure 1.19E-10mmHg at 25°C
Appearance Crystalline Powder or Silky Needles
Color White to off-white
Merck 14,8061
BRN 6112655
PH 6.0 (10g/l, H2O, 20℃)
Storage Condition Keep in dark place,Inert atmosphere,2-8°C
Sensitive Light Sensitive
Refractive Index -250 ° (C=2, EtOH)
MDL MFCD00151248
Use K channel blocker.
In vitro study Quinine blocked the Cx36 and Cx50 junction currents in a reversible and concentration-dependent manner, with half-maximal blocking concentrations of 32 mM and 73 mM, respectively. Quinine induces a slow transition between the open and fully closed states, which reduces the open probability of the channel. Quinine prevents certain types of gap junction channels, including those between neurons, from forming through CX36. Quinine, a K-channel blocker, prevents the formation of tumor necrosis factor (TNF) and subsequent liver DNA fragmentation and liver enzyme leakage. Quinine caused a Fos-like immune response (FLI) to concentrate in the medial third nucleus; Acid caused a more widespread FLI concentration more laterally. Quinine had a relatively weak effect on doxorubicin accumulation but completely restored doxorubicin sensitivity in resistant cells. Quinine also modified intracellular accumulation of doxorubicin, suggesting a modified intracellular drug distribution. Quinine predominantly blocks the voltage dependence in the whole-cell potassium current (IK). Quinine has also been used to dependently reduce sodium current (INa) while leaving calcium current (ICA) relatively unaffected.

 

 Reference Information

FEMA 2976 | QUININE HYDROCHLORIDE
appearance White amorphous or crystalline powder
solubility Water: 62.5g/l (20 C), soluble in ethanol, glycerol and chloroform, slightly soluble in ether.
Use K channel blocker.
biological activity Quinine HCl Dihydrate is a natural white crystalline alkaloid, with fever (heat), anti-malaria, analgesic, analgesic, anti-inflammatory properties, bitter taste.
Target Value

Last Update:2023-12-21 00:21:33

6119-47-7 - Introduction

Solubility in water: 62.5g/l (20 C), soluble in ethanol, glycerol and chloroform, slightly soluble in ether.

 

Details:

Quinine hydrochloride dihydrate

Mol Download Chemical properties

CAS:

6119-47-7

MF:

C20H27ClN2O3

MW:

378.9

EINECS:

612-097-2

MDL No.:

MFCD00151248

Properties

Melting point:

115-116 °C (dec.)(lit.)

alpha 

[α]D20 -245~-255° (c=2, dil. HCl) (After Drying)

FEMA 

2976 | QUININE HYDROCHLORIDE

refractive index 

-250 ° (C=2, EtOH)

Flash point:

122 °C

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

H2O: soluble0.25/5g/mL, clear, colorless

form 

Crystalline Powder or Silky Needles

color 

White to off-white

PH

6.0 (10g/l, H2O, 20℃)

Odor

odorless

Odor Type

odorless

optical activity

[α]22/D 235°, c = 2 in 0.1 M HCl

Water Solubility 

Sparingly soluble in water.(0.26 g/L) (25°C),

Sensitive 

Light Sensitive

Merck 

14,8061

BRN 

6112655

InChIKey

MPQKYZPYCSTMEI-HPVDNOPASA-N


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