CAS: 189188-57-6 Tegaserod maleate

Details:

Product Name: Tegaserod maleate
Synonyms: SDZ-HTF-919;TEGASEROD MALEATE;2-[(5-METHOXY-1H-INDOL-3-YL)METHYLENE]-N-PENTYLHYDRAZINECARBOXIMIDAMIDE, MALEATE;2-[(5-methoxy-1h-indole-3-yl)methylene]-n-pentylcarbazimidamide hydrogen maleate;1-[(5-methoxy-3-indolylidene)methylamino]-2-pentylguanidine;ZELMAC;TegaserodMalate;TegastrodMaleate
CAS: 189188-57-6
MF: C20H27N5O5
MW: 417.46
EINECS: 630-469-2
Product Categories: Active Pharmaceutical Ingredients;Chiral Compound;Intermediates & Fine Chemicals;Pharmaceuticals;Tegaserod
Mol File: 189188-57-6.mol
Tegaserod maleate Structure
Tegaserod maleate Chemical Properties
Melting point  180-183°C
storage temp.  -20°C Freezer
form  powder
color  white to beige
CAS DataBase Reference 189188-57-6(CAS DataBase Reference)
Safety Information
MSDS Information
Tegaserod maleate Usage And Synthesis
Description Tegaserod maleate was launched as a new oral treatment of constipationpredominant or diarrhea-predominant irritable bowel syndrome. It can be prepared by condensation of the 5-methoxy-3-formylindole with the appropriate aminoguanidine. Tegaserod is a selective partial agonist of the excitatory 5-HT4 receptor (K1 = 18 nM in human caudate membranes) and was designed from the endogenous full agonist, seretonin. In the model of potentiation of the electrically stimulated contraction of longitudinal muscle of guinea pig ileum, Tegaserod exhibited a low-efficacy agonistic activity compared with serotonin. However, it appeared more potent in several studies on intestinal mucosal tissue from various species including man. A lack of effect on the QTc interval was shown in rabbits then confirmed during clinical studies. Tegaserod is also clinically developed for the treatment of other functional GI disorders such as functional dyspepsia and gastroesophageal reflux disease (GERD).
Chemical Properties White Powder
Originator Novartis (Switzerland)
Uses Tegaserod is a gastroproeinetic used in the treatment of irritable bowel syndrome. A selective serotonin 5HT4-receptor partial agonist.