Add time:08/09/2019         Source:sciencedirect.com

The interaction of mercaptoundecahydrododecaborate (cas 12294-22-3) (B12H11SH2−, BSH) with phosphatidylcholine was investigated in this study in order to illuminate possible uptake mechanisms of BSH in tumor cells. BSH has been used clinically in Japan as a boron containing agent in patients with malignant brain tumors for boron neutron capture therapy (BNCT). After infusion, BSH accumulates selectively in tumor tissue. Little is known for the mechanism of boron uptake to tumor cells. Fourier transform infrared (FTIR) spectrometry was used to quantify BSH (at wavenumber 2490 cm−1) and phosphatidylcholine (at wavenumber 2850–2970 cm−1). After extraction into carbon tetrachloride (CCl4), we could find an absorbance maximum at 2490 cm−1 as a B–H band in the mixture of BSH with phosphatidylcholine, which is attributed to a BSH–phosphatidylcholine complex, which could dissolve well in CCl4. The molar ratio of BSH to phosphatidylcholine in the CCl4 solution was at most one mole of BSH to two moles of phosphatidylcholine independent of the excess BSH. The doubly negatively charged BSH can interact with two phosphatidylcholine molecules through their singly positively charged choline residues. These ion pairs could be responsible for membrane binding and penetration, and for cell internalization.

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