Add time:08/10/2019         Source:sciencedirect.com

We investigated insecticidal effects of IMINOCTADINE (cas 13516-27-3) liquid formulation, a fungicide containing iminoctadine triacetate, on the silkworm Bombyx mori that is an important domesticated insect. Iminoctadine liquid formulation was incorporated in an artificial diet and fed to silkworms for 24 h on the first day of either the third or fourth instar, thereafter reared without the fungicide. Third instar larvae that ingested the diet containing 1% (wt/wt) iminoctadine liquid formulation died within 24 h (subacute toxicity), and those that ingested either 0.1% or 0.3% iminoctadine liquid formulation developed to the pharate fourth stage and then became deficient in molting (delayed toxicity). In fourth instar larvae, iminoctadine liquid formulation exhibited subacute toxicity and delayed toxicity at 0.3% and >1%, respectively. Furthermore, we fed the larvae a diet with iminoctadine liquid formulation for 24 h at different intervals in the inter-molting period of the third and fourth instar. Iminoctadine liquid formulation administered at an earlier stage in the inter-molting period exerted a more severe effect than a later administration. Iminoctadine triacetate, an anti-fungal ingredient in the iminoctadine liquid formulation, exhibited toxicity similar to that of the liquid formulation.

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