Add time:08/24/2019 Source:sciencedirect.com
ambenonium chloride (cas 115-79-7) was administered orally in a dosage of 6 mg/kg/day to rats for 14–360 days.Motor end-plate fine structure and junctional AChR were quantitatively analyzed in red (soleus) and white (EDL) muscle fibers. In treated animals, degeneration and simplification of postsynaptic folds and widening of synaptic clefts were often observed in soleus end-plates, but infrequently in EDL end-plates. On the other hand, the postsynaptic AChR was reduced markedly in both soleus and EDL end-plates. No presynaptic changes were observed.These results show that long-term administration of Anti-ChE agents in myasthenia gravis may have an adverse effect on neuromuscular transmission.
We also recommend Trading Suppliers and Manufacturers of ambenonium chloride (cas 115-79-7). Pls Click Website Link as below: cas 115-79-7 suppliers
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View