Add time:10/01/2019 Source:sciencedirect.com
A series of oximinopropanolamines derived from Dicyclopropyl ketone (cas 1121-37-5), in which the amine substituents were alkyl, cycloalkyl, aryl and aralkyl groups, has been synthesized. The β-adrenergic blocking properties were determined on anaesthetized rats. Two N-aralkyl derivatives were found to be as potent as propranolol and compound 11 was twice as active as propranolol. Some structure-activity relationships are discussed.
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