Add time:09/28/2019 Source:infona.pl
Herein we report the identification of two new fatty acid amide hydrolase (FAAH) inhibitor lead series with FAAH k inact /K i potency values greater than 1500M −1 s −1 . The two novel spirocyclic cores, 7-azaspiro[3.5]nonane and 1-Oxa-8-azaspiro[4.5]decane (cas 176-92-1), clearly distinguished themselves from the other spirocyclic cores on the basis of their superior potency for FAAH. Lead compounds from these two series have suitable FAAH potency and selectivity for additional medicinal chemistry optimization.
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