Add time:07/17/2019         Source:sciencedirect.com

Background and purpose5-Chloro-2,4-dihydroxypyridine (Gimeracil (cas 103766-25-2)) is a component of an oral fluoropyrimidine derivative S-1. Gimeracil is originally added to S-1 to yield prolonged 5-FU concentrations in tumor tissues by inhibiting dihydropyrimidine dehydrogenase, which degrades 5-FU. We found that Gimeracil by itself had the radiosensitizing effect.

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