- Production Method of BRN 4763587
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BRN 4763587 (CAS NO.: 111711-92-3), with its other name of 2-Pyrrolidinone, 5-(1-methylethoxy)-1-((3-(trifluoromethyl)phenyl)sulfonyl)-, could be produced through many synthetic methods.
Following is one of the synthesis routes: Sodium borohydride reduction of succinimide in isopropanol, according to the Speckamps procedure, gives 5-isopropoxy-2-pyrrolidinone. Condensation with 3-trifluoromethylbenzenesulfonyl chloride (2) is effected with n-butyllithium in tetrahydrofuran at low temperature to give RU-47067 in an overall yield of 38%.
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