As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
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inquiry1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% 5. Chi
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/1095.html Product Name 5-(1-Piperazinyl)benzofuran-2-carboxamide CAS No.
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryOur advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent
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inquiryHenan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com
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inquiryName: 1-(2-Aminocarbonylbenzofuran-5-yl)piperazine CAS No.: 183288-46-2 Formula: C13H15N3O2 Molecular We
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inquiry5-(1-Piperazinyl)benzofuran-2-carboxamide CAS:183288-46-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in hig
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryShanghai SOYOUNG onsite assessment conducted by Bureau Veritas commissioned at June 2018. Assessed Supplier of Shanghai SOYOUNG is a faithful and professional supplier of health raw materials in pharmacy, food, cosmetic and other fields for many ye
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inquiryAppearance: White or off-white Solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:S
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:183288-46-2
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inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
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inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:At room temperature Package:10g/bag,or as your request Application:For medicine , pesticide intermediates Transportation:as your request Port:Shanghai, Ningb
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inquiryCHENGDU YANXI is a comprehensive manufacturer and an international distribution of products throughout the world. Specialized in Scrap metal, Chemical raw materials, Paper products and color industry. We aim to become leading position in global dis
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inquiry5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With ammonium hydroxide at 20℃; for 10h; | 97% |
piperazine
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 120℃; for 6h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere; | 93.9% |
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With ammonium hydroxide In 1-methyl-pyrrolidin-2-one at 40 - 50℃; for 21h; Large scale; | 80% |
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Stage #1: 5-(4-acetylpiperazin-1-yl)benzofuran-2-carboxamide With hydrogenchloride In ethanol for 8h; Reflux; Stage #2: With ammonium hydroxide In ethanol at 20℃; for 1h; | 78% |
tert-butyl 4-(2-carbamoyl-1-benzofuran-5-yl)piperazine-1-carboxylate
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With hydrogenchloride In water at 35 - 50℃; for 1h; Large scale; | 77.86% |
In methanol hydrochloride |
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With ammonia In methanol at 25 - 30℃; | 73.1% |
piperazine
5-chlorobenzofuran-2-carboxamide
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With copper dichloride In dimethyl sulfoxide at 150℃; Reagent/catalyst; Solvent; | 72% |
piperazine
5-bromo-2-carboxamidobenzo[b]furan
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With copper(II) cyanide In N,N-dimethyl-formamide at 150℃; Reagent/catalyst; Solvent; | 70% |
piperazine
5-bromo-2-carboxamidobenzo[b]furan
pyrographite
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With hydrogenchloride; Pd(dba)2 In water; ethyl acetate; toluene |
5-bromo-2-carboxamidobenzo[b]furan
1-t-Butoxycarbonylpiperazine
A
tert-butyl 4-(2-carbamoyl-1-benzofuran-5-yl)piperazine-1-carboxylate
B
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With hydrogenchloride; Pd(dba)2 In diethylene glycol dimethyl ether; water |
5-nitro-1-benzofuran-2-carboxamide
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogen / methanol / 14 h / 35 - 60 °C / 4500.45 Torr 2: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 3: hydrogen bromide; 4-hydroxy-benzoic acid / acetic acid / 50 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: water; Pd/C; ammonium formate / methanol / 2 h / 30 - 45 °C 2.1: 2 h / 150 - 155 °C 2.2: 6 h / 150 - 155 °C View Scheme | |
Multi-step reaction with 3 steps 1: hydrogen / methanol / 14 h / 35 - 60 °C / 4500.45 Torr 2: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 3: 4-hydroxy-benzoic acid; hydrogen bromide; acetic acid / 3 h / 50 °C View Scheme |
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 2: hydrogen bromide; 4-hydroxy-benzoic acid / acetic acid / 50 °C View Scheme | |
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 2: 4-hydroxy-benzoic acid; hydrogen bromide; acetic acid / 3 h / 50 °C View Scheme |
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With hydrogen bromide; 4-hydroxy-benzoic acid In acetic acid at 50℃; | |
With hydrogen bromide; acetic acid; 4-hydroxy-benzoic acid at 50℃; for 3h; |
2-Formylphenoxyacetic acid
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: sulfuric acid; nitric acid / 5 - 35 °C 2.1: acetic anhydride / 0.25 h / 35 °C 2.2: 8 h / 125 °C 3.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 35 - 115 °C 3.2: 10 °C / pH 8 - 9 4.1: hydrogen / methanol / 14 h / 35 - 60 °C / 4500.45 Torr 5.1: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 6.1: hydrogen bromide; 4-hydroxy-benzoic acid / acetic acid / 50 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: sulfuric acid / water / 0.25 h / 5 - 35 °C 1.2: 2.25 h / 5 - 35 °C 2.1: acetic anhydride / 0.25 h / 35 °C 2.2: 8 h / 125 °C 3.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 0.5 h / 70 - 115 °C 4.1: ammonia / N,N-dimethyl-formamide / 10 °C / pH 8 - 9 5.1: hydrogen / methanol / 14 h / 35 - 60 °C / 4500.45 Torr 6.1: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 7.1: 4-hydroxy-benzoic acid; hydrogen bromide; acetic acid / 3 h / 50 °C View Scheme |
salicylaldehyde
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: sodium hydroxide / water / 3 h / 30 - 100 °C 2.1: sulfuric acid; nitric acid / 5 - 35 °C 3.1: acetic anhydride / 0.25 h / 35 °C 3.2: 8 h / 125 °C 4.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 35 - 115 °C 4.2: 10 °C / pH 8 - 9 5.1: hydrogen / methanol / 14 h / 35 - 60 °C / 4500.45 Torr 6.1: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 7.1: hydrogen bromide; 4-hydroxy-benzoic acid / acetic acid / 50 °C View Scheme | |
Multi-step reaction with 8 steps 1.1: sodium hydroxide / water / 3 h / 30 - 100 °C 2.1: sulfuric acid / water / 0.25 h / 5 - 35 °C 2.2: 2.25 h / 5 - 35 °C 3.1: acetic anhydride / 0.25 h / 35 °C 3.2: 8 h / 125 °C 4.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 0.5 h / 70 - 115 °C 5.1: ammonia / N,N-dimethyl-formamide / 10 °C / pH 8 - 9 6.1: hydrogen / methanol / 14 h / 35 - 60 °C / 4500.45 Torr 7.1: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 8.1: 4-hydroxy-benzoic acid; hydrogen bromide; acetic acid / 3 h / 50 °C View Scheme |
2-(2-formyl-4-nitrophenoxy)acetic acid
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: acetic anhydride / 0.25 h / 35 °C 1.2: 8 h / 125 °C 2.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 35 - 115 °C 2.2: 10 °C / pH 8 - 9 3.1: hydrogen / methanol / 14 h / 35 - 60 °C / 4500.45 Torr 4.1: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 5.1: hydrogen bromide; 4-hydroxy-benzoic acid / acetic acid / 50 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: acetic anhydride / 0.25 h / 35 °C 1.2: 8 h / 125 °C 2.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 0.5 h / 70 - 115 °C 3.1: ammonia / N,N-dimethyl-formamide / 10 °C / pH 8 - 9 4.1: hydrogen / methanol / 14 h / 35 - 60 °C / 4500.45 Torr 5.1: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 6.1: 4-hydroxy-benzoic acid; hydrogen bromide; acetic acid / 3 h / 50 °C View Scheme |
5-nitrobenzofuran-2-carboxylic acid
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 35 - 115 °C 1.2: 10 °C / pH 8 - 9 2.1: hydrogen / methanol / 14 h / 35 - 60 °C / 4500.45 Torr 3.1: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 4.1: hydrogen bromide; 4-hydroxy-benzoic acid / acetic acid / 50 °C View Scheme | |
Multi-step reaction with 5 steps 1: thionyl chloride / toluene; N,N-dimethyl-formamide / 0.5 h / 70 - 115 °C 2: ammonia / N,N-dimethyl-formamide / 10 °C / pH 8 - 9 3: hydrogen / methanol / 14 h / 35 - 60 °C / 4500.45 Torr 4: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 5: 4-hydroxy-benzoic acid; hydrogen bromide; acetic acid / 3 h / 50 °C View Scheme |
5-aminobenzofuran-2-carboxylic acid methyl ester
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tributyl-amine / 43 h / 73 - 77 °C 2: sulfuric acid / 0.25 h / 25 - 102 °C 3: ammonia / methanol / 25 - 30 °C View Scheme |
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sulfuric acid / 0.25 h / 25 - 102 °C 2: ammonia / methanol / 25 - 30 °C View Scheme |
5-(4-formylpiperazin-1-yl)-1-benzofuran-2-carboxamide
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With hydrogenchloride In water at 45 - 50℃; for 1h; | 24 g |
N,N-bis(chloro-2-ethyl)amine
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Stage #1: 5-amino-1-benzofuran-2-carboxamide; N,N-bis(chloro-2-ethyl)amine at 150 - 155℃; for 2h; Stage #2: With tributyl-amine In 1-methyl-pyrrolidin-2-one at 150 - 155℃; for 6h; | 5.6 g |
ethyl 5-nitrobenzo[d]furan-2-carboxylate
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: formamide; sodium methylate / 1-methyl-pyrrolidin-2-one / 2 h / 20 - 25 °C 2.1: water; Pd/C; ammonium formate / methanol / 2 h / 30 - 45 °C 3.1: 2 h / 150 - 155 °C 3.2: 6 h / 150 - 155 °C View Scheme |
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: formamide; sodium methylate / methanol / 1 h / 20 - 30 °C / Large scale 2: hydrogenchloride / water / 1 h / 35 - 50 °C / Large scale View Scheme |
5-nitrobenzofuran-2-carbonyl chloride
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: ammonia / N,N-dimethyl-formamide / 10 °C / pH 8 - 9 2: hydrogen / methanol / 14 h / 35 - 60 °C / 4500.45 Torr 3: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 4: 4-hydroxy-benzoic acid; hydrogen bromide; acetic acid / 3 h / 50 °C View Scheme |
5-fluoro-2-hydroxybenzaldehyde
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium methylate / diethyl ether / 0.2 h / 20 °C / Inert atmosphere 1.2: 8 h / 20 °C / Inert atmosphere 2.1: potassium carbonate / dimethyl sulfoxide / 6 h / 120 °C / Inert atmosphere View Scheme |
5-bromosalicyclaldehyde
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium carbonate / ethyl acetate / 6 h / Reflux 1.2: 3 h / 80 °C 2.1: N,N-dimethyl-formamide / 6 h / 140 °C 3.1: thionyl chloride / 1,2-dichloro-ethane / 4 h / 60 °C 4.1: ammonia / tetrahydrofuran / 0.5 h / 25 °C / 2250.23 Torr View Scheme |
5-bromobenzo[b]furan-2-carboxylic acid
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide / 6 h / 140 °C 2: thionyl chloride / 1,2-dichloro-ethane / 4 h / 60 °C 3: ammonia / tetrahydrofuran / 0.5 h / 25 °C / 2250.23 Torr View Scheme |
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: thionyl chloride / 1,2-dichloro-ethane / 4 h / 60 °C 2: ammonia / tetrahydrofuran / 0.5 h / 25 °C / 2250.23 Torr View Scheme |
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With ammonia In tetrahydrofuran at 25℃; under 2250.23 Torr; for 0.5h; | 196 g |
3-(4-chlorobutyl)-5-cyanoindole
5-(1-piperazinyl)benzofuran-2-carboxamide
vilazodone
Conditions | Yield |
---|---|
Stage #1: 3-(4-chlorobutyl)-5-cyanoindole With sodium iodide In N,N-dimethyl-formamide at 25 - 30℃; for 0.25h; Stage #2: 5-(1-piperazinyl)benzofuran-2-carboxamide With tetrabutylammomium bromide; sodium hydrogencarbonate In N,N-dimethyl-formamide at 110 - 115℃; for 1.25h; Reagent/catalyst; Temperature; Time; Solvent; | 95.7% |
With sodium carbonate In water at 90 - 100℃; | 94% |
Stage #1: 5-(1-piperazinyl)benzofuran-2-carboxamide With hydrogenchloride In water at 20 - 35℃; pH=6.5 - 7; Stage #2: 3-(4-chlorobutyl)-5-cyanoindole With sodium carbonate In water; isopropyl alcohol at 75 - 85℃; for 12h; Reagent/catalyst; pH-value; | 94% |
3-(4-chlorobutyl)-5-cyanoindole
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Stage #1: 3-(4-chlorobutyl)-5-cyanoindole With sodium iodide In N,N-dimethyl-formamide at 25 - 30℃; for 0.25h; Stage #2: 5-(1-piperazinyl)benzofuran-2-carboxamide With tetrabutylammomium bromide; sodium hydrogencarbonate In N,N-dimethyl-formamide at 110 - 115℃; for 1.25h; Temperature; Solvent; Reagent/catalyst; | 95.7% |
3-(4-hydroxybutyl)-1H-indole-5-carbonitrile
5-(1-piperazinyl)benzofuran-2-carboxamide
vilazodone
Conditions | Yield |
---|---|
With trifluoroacetic acid at 60℃; for 12h; Temperature; | 91.2% |
5-(1-piperazinyl)benzofuran-2-carboxamide
5-[4-[4-[5-cyano-1-(p-toluenesulfonyl)-1H-indol-3-yl]butyl]piperazin-1-yl]benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With triethylamine In 1-methyl-pyrrolidin-2-one at 120℃; for 5h; | 86% |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With triethylamine; potassium iodide In N,N-dimethyl-formamide at 20 - 90℃; for 49h; Inert atmosphere; | 85% |
With tributyl-amine In 1-methyl-pyrrolidin-2-one at 25 - 130℃; for 24h; | 7% |
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With triethylamine In 1-methyl-pyrrolidin-2-one at 120℃; for 6h; Reagent/catalyst; Solvent; | 84% |
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With triethylamine In 1-methyl-pyrrolidin-2-one at 120℃; for 5h; | 82% |
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With triethylamine In 1-methyl-pyrrolidin-2-one at 120℃; for 5h; | 79% |
5-(1-piperazinyl)benzofuran-2-carboxamide
methanesulfonic acid 5-cyano-3-(4-methanesulfonyloxy-butyl)-1H-indol-6-yl ester
methanesulfonic acid 3-{4-[4-(2-carbamoyl-benzofuran-5-yl)-piperazin-1-yl]-butyl}-5-cyano-1H-indol-6-yl ester
Conditions | Yield |
---|---|
With 1-methyl-pyrrolidin-2-one at 120℃; | 77% |
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With triethylamine In 1-methyl-pyrrolidin-2-one at 120℃; for 5h; | 76% |
3-(4-oxobutyl)-1H-indole-5-carbonitrile
5-(1-piperazinyl)benzofuran-2-carboxamide
vilazodone
Conditions | Yield |
---|---|
Stage #1: 5-(1-piperazinyl)benzofuran-2-carboxamide With sodium cyanoborohydride In methanol at 20℃; Stage #2: 3-(4-oxobutyl)-1H-indole-5-carbonitrile In methanol at 20℃; for 18h; | 75.21% |
3-(4-oxobutyl)-1H-indole-5-carbonitrile
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Stage #1: 5-(1-piperazinyl)benzofuran-2-carboxamide With methanol; sodium cyanoborohydride at 20℃; Stage #2: 3-(4-oxobutyl)-1H-indole-5-carbonitrile at 20℃; for 18.25h; | 75.21% |
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With triethylamine In 1-methyl-pyrrolidin-2-one at 120℃; for 5.5h; | 72% |
C14H15ClN2
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With 1-methyl-pyrrolidin-2-one; triethylamine at 20 - 120℃; for 14h; |
3-(4-chloro-butyl)-2,3-dihydro-1H-indole-5-carbonitrile
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Stage #1: 3-(4-chloro-butyl)-2,3-dihydro-1H-indole-5-carbonitrile; 5-(1-piperazinyl)benzofuran-2-carboxamide With 1-methyl-pyrrolidin-2-one at 125℃; for 24h; Stage #2: With sodium hydroxide In water at 0℃; pH=10; Stage #3: With hydrogenchloride In water; acetone pH=3; |
3-(4-oxobutyl)-1H-indole-5-carbonitrile
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Stage #1: 3-(4-oxobutyl)-1H-indole-5-carbonitrile; 5-(1-piperazinyl)benzofuran-2-carboxamide With sodium cyanoborohydride In methanol at 10 - 20℃; for 24.25h; Stage #2: With hydrogenchloride In tetrahydrofuran; water at 20℃; Product distribution / selectivity; |
1-methyl-pyrrolidin-2-one
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; ice-water; water; ethyl acetate |
(6-chloro-1-hexyn-1-yl)trimethylsilane
5-(1-piperazinyl)benzofuran-2-carboxamide
5-[4-(6-trimethylsilanyl-hex-5-ynyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid amide
Conditions | Yield |
---|---|
With triethylamine In acetonitrile for 72h; Heating; |
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