100-38-9

Basic information

• Product Name: 2-Diethylaminoethanethiol
• Synonyms: n,n-diethyl-cysteamine;N-Diaethyl cysteamin;n-diaethylcysteamin;n-diethylcysteamine;Triethylamine, 2-mercapto-;DIETHYLAMINOETHANE THIOL;DIETHYLAMINOETHANETHIOL(2-);2-(DIETHYLAMINO)ETHANETHIOL
• CAS NO: 100-38-9
• Molecular Formula: C₆H₁₅NS
• Molecular Weight: 133.26
• EINECS: 202-846-8
• Mol File: 100-38-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 161.588 °C at 760 mmHg
• Flash Point: 51.527 °C
• Appearance: /
• Density: 0.899 (estimate)
• Vapor Pressure: 2.26mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• PKA: 8.89±0.10(Predicted)
• CAS DataBase Reference: 2-Diethylaminoethanethiol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Diethylaminoethanethiol(100-38-9)
• EPA Substance Registry System: 2-Diethylaminoethanethiol(100-38-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• Hazardous Substances Data: 100-38-9(Hazardous Substances Data)

Usage

Chemical Properties

Colourless to Pale Orange Oil

Uses

2-(Diethylamino)ethanethiol is an intermediate in the synthesis of (S)-Pregabalin (P704790).

Synthesis Reference(s)

Journal of the American Chemical Society, 70, p. 950, 1948 DOI: 10.1021/ja01183a018

InChI:InChI=1/C6H15NS/c1-3-7(4-2)5-6-8/h8H,3-6H2,1-2H3

Upstream product

• 420-12-2 thirane 
• 816-43-3 lithium diethylamide 
• 109-89-7 diethylamine 
• 60-29-7 diethyl ether 
• 55847-36-4 2-chloroethane thioacetate 
• 100-35-6 2-(diethylamino)ethyl chloride 
• 3326-89-4 [1,3]oxathiolan-2-one 
• 93029-88-0 Dithiokohlensaeure-S-<2-diethylamino-ethylester>-S-methylester 
• 5842-22-8 thiocarbonic acid O-ethyl ester-S-(2-hydroxy-ethyl ester) 
• 5978-05-2 Butylcarbamidsaeure-<2-mercapto-aethylester> 
• 100-37-8 2-(Diethylamino)ethanol 
• 64-17-5 ethanol 
• 78-53-5 O,O-diethyl S-(2-diethylaminoethyl) thiophosphate 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 94876-28-5 2-(2-diethylamino-ethylsulfanyl)-1,1-diphenyl-ethanol 
• 63868-77-9 N-[3-(2-diethylamino-ethylmercapto)-propyl]-phthalimide 
• 7708-55-6 benzyl 2-(diethylamino)ethyl sulfide 
• 109313-26-0 2-chloro-4-nitro-thiobenzoic acid S-(2-diethylamino-ethyl ester); hydrochloride 
• 7579-62-6 diethyl-[2-(2,4-dinitro-phenylsulfanyl)-ethyl]-amine; hydrochloride 
• 131252-76-1 (2,6-dimethyl-phenyl)-thiocarbamic acid S-(2-diethylamino-ethyl ester) 
• 82-99-5 diphenyl-thioacetic acid S-(2-diethylamino-ethyl ester) 
• 4358-87-6 (RS)-methyl mandelate 
• 96116-65-3 diethyl-(2-cyclohexylmercapto-ethyl)-amine 
• 101428-02-8 mesityl-thiocarbamic acid S-(2-diethylamino-ethyl ester) 
• 101265-99-0 2-hydroxy-4-nitro-thiobenzoic acid S-(2-diethylamino-ethyl ester) 
• 23713-11-3 dithiophosphoric acid O,O'-diethyl ester-S-(2-diethylamino-ethyl ester) 
• 195195-29-0 2,7-bis-(2-diethylamino-ethylmercapto)-4-methyl-[1,8]naphthyridine 

Relevant articles and documents

Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery

The ability to control chemical functionality is an exciting feature of modern polymer science that enables precise design of drug delivery systems. Ring-opening polymerization of functional monomers has emerged as a versatile method to prepare clinically translatable degradable polyesters.1 A variety of functional groups have been introduced into lactones; however, the direct polymerization of tertiary amine functionalized cyclic esters has remained elusive. We report a strategy that enabled the rapid synthesis of >130 lipocationic polyesters directly from functional monomers without protecting groups. These polymers are highly effective for siRNA delivery at low doses in vitro and in vivo.

-

-

Preparation method of aliphatic mercaptan

The invention provides a novel method for preparing (CH3CH2) 2NCH2CH2SH, i.e., the reaction is carried out at a lower temperature, and the reaction is controllable by adopting a manner of dropwise adding materials, so that the safe production is realized.

Microwave-assisted activation and modulator removal in zirconium MOFs for buffer-free CWA hydrolysis

A novel, facile and efficient method was developed for the activation of acetic acid modulated zirconium MOFs. The protocol involves briefly heating the material in water using microwave irradiation. MOF-808, DUT-84 and UiO-66 were all activated in this manner to remove the modulator and organic solvent from the framework post synthesis, with retention of MOF integrity post activation. The degree of activation was characterised by the use of TGA and NMR. The catalytic activity of the activated MOFs and their non-activated counterparts was investigated for chemical warfare agent (CWA) hydrolysis. Upon activation, an increase in the rate of hydrolysis was observed in the degradation of CWA simulant dimethyl 4-nitrophenyl phosphate (DMNP). MOF-808 and DUT-84 were also screened as catalysts for the hydrolysis of the V-series agent VM, with remarkable half-lives obtained for MOF-808 in the absence of any buffers. Currently employed MOF activation procedures involve the use of additional organic solvents post synthesis; we believe this method to be ideally efficacious for the organic desolvation of zirconium MOFs and removing modulator additives.