1000045-32-8

Basic information

• Product Name: 1-chloro-2-(3-methoxy-propoxy)-4-methyl-benzene
• Synonyms: 1-chloro-2-(3-methoxy-propoxy)-4-methyl-benzene
• CAS NO: 1000045-32-8
• Molecular Weight: 214.692
• Mol File: 1000045-32-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-chloro-2-(3-methoxy-propoxy)-4-methyl-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-2-(3-methoxy-propoxy)-4-methyl-benzene(1000045-32-8)
• EPA Substance Registry System: 1-chloro-2-(3-methoxy-propoxy)-4-methyl-benzene(1000045-32-8)

Safety Data

• Hazardous Substances Data: 1000045-32-8(Hazardous Substances Data)

Upstream product

• 1589-49-7 methoxypropanol 
• 615-74-7 2-chloro-5-methylphenol 

Downstream Products

• 1000045-33-9 4-(bromomethyl)-1-chloro-2-(3-methoxypropoxy)benzene 

Relevant articles and documents

ASPARTYL PROTEASE INHIBITORS

The invention provides compounds of the formula (I) wherein A is selected from the partial structures A1, A2 and A3; Ry and Ry' are both hydrogen, or Ry and Ry' together with the nitrogen atom to which they are attached form a cyclic amine such as morpholine, piperidine, piperazine or pyrrolidine; L is NHNH, CH2NH, O or S; Y is NH, NHNH, NHC(=O), S(=O)2NH, NHS(=O)2, CH2, CH2NH, O, S or S(=0)p; Q is aryl or heterocyclyl; Z is O, S, NRa or S(=0)p; m is O, 1 or 2; n is O, 1, 2 or 3; p is independently 1 or 2; q is 0 or 1; Ra is H or C1-C4alkyl; R1 is hydrogen, C1-C6alkyl, C3-C7cycloalkylC0-C3alkyl, arylC0-C3alkyl or heterocyclylC0-C3alkyl, R4'' is H or C1-C6alkyl; or R4' and R4'' together with the carbon atom to which they are attached define a C3-C6cycloalkyl; W is H, C1-C6alkyl, C3-C7ycycloalkyl, aryl or heterocyclyl; or a pharmaceutically acceptable salt, hydrate or N-oxide thereof. The compounds of the invention are inhibitors of aspartyl proteases such as renin and are among other things useful for the treatment of conditions associated with activities of the RAS, such as hypertension, heart failure and renal insufficiency.