1000376-88-4Relevant articles and documents
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists
Manera, Clementina,Cascio, Maria Grazia,Benetti, Veronica,Allara, Marco,Tuccinardi, Tiziano,Martinelli, Adriano,Saccomanni, Giuseppe,Vivoli, Elisa,Ghelardini, Carla,Di Marzo, Vincenzo,Ferrarini, Pier Luigi
, p. 6505 - 6510 (2008/09/20)
A series of new 1,8-naphthyridine and quinoline derivatives were synthesized and evaluated for their cannabinoid receptor affinity. In particular, compounds 2, 5, 11, and 13 showed a high CB2 affinity and CB2 versus CB1 selectivity, in agreement with molecular modeling studies. Furthermore, compound 2 also exhibited in vivo antinociceptive effects.