1000590-07-7Relevant articles and documents
Microwave-assisted, palladium-catalyzed intramolecular direct arylation for the synthesis of novel fused heterocycles
Wu, Jinlong,Nie, Liang,Luo, Jialu,Dai, Weimin
, p. 2728 - 2732 (2008/02/12)
An efficient synthesis of novel fused heterocycles has been established via microwave-assisted palladium-catalyzed intramolecular direct arylation. The acyclic aryl bromides are readily available from microwave-assisted one-pot annulation of N-(2-bromobenzyl)-2-aminophenols and ethyl 2-bromoalkanoates. The intramolecular direct arylation is then performed in the presence of palladium(II) acetate and dppf (10 mol% each) in toluene using potassium carbonate (2 equiv) as the base under microwave heating (150°C, 1 h) to afford the products in 43-99% yields. Steric effect is observed for Ar-Ar bond formation, giving a substantial amount of the debromination byproduct. Georg Thieme Verlag Stuttgart.