1000679-96-8

Basic information

• Product Name: 1,1-bis(4-fluorophenyl)-3-phenylprop-2-yn-1-ol
• Synonyms: 1,1-bis(4-fluorophenyl)-3-phenylprop-2-yn-1-ol
• CAS NO: 1000679-96-8
• Molecular Weight: 320.338
• Mol File: 1000679-96-8.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 1,1-bis(4-fluorophenyl)-3-phenylprop-2-yn-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-bis(4-fluorophenyl)-3-phenylprop-2-yn-1-ol(1000679-96-8)
• EPA Substance Registry System: 1,1-bis(4-fluorophenyl)-3-phenylprop-2-yn-1-ol(1000679-96-8)

Safety Data

• Hazardous Substances Data: 1000679-96-8(Hazardous Substances Data)

Upstream product

• 345-92-6 4,4'-Difluorobenzophenone 
• 536-74-3 phenylacetylene 
• 365-24-2 4,4'-difluorobenzhydryl alcohol 

Downstream Products

• 1000680-06-7 C₃₇H₂₈F₂O 
• 1192167-50-2 1,1-bis(4-fluorophenyl)-5,7-dimethyl-3-phenyl-1H-inden-6-ol 
• 1242072-88-3 4-(bis(4-fluorophenyl)methyl)-2-methyl-5-phenylthiazole 
• 1263098-35-6 4-(bis(4-fluorophenyl)methyl)-2,5-diphenyloxazole 
• 850833-47-5 2,8-difluoro-5,11-bis(4-fluorophenyl)-6,12-diphenyltetracene 

Relevant articles and documents

Lewis Acid-Catalyzed [4+2] Annulation between Propargylic Alcohols with Benzo[d]isoxazoles

An unprecedented copper(II) trifluoromethanesulfonate-catalyzed [4+2] cascade annulation of propargylic alcohols with benzo[d]isoxazoles proceeds through a sequential ring opening/Meyer–Schuster rearrangement/intermolecular cyclization. This protocol, whi

In Situ Generation of Allenes and their Application to One-Pot Assembly of Functionalized Fluoreno[3,2-b]furans by Calcium-Catalyzed, Regioselective, 3-Component Reactions

We have developed a novel synthetic methodology for the preparation of tetra-annulated fluorenofurans and fluorenopyrans using calcium(II)-catalyzed one-pot, three-component reaction. In this reaction, tert-propargyl alcohols react with 1,3-dicarbonyls to form tetra-substituted allenes, which are subsequently undergoing regiodivergent annulation with sec-propargyl alcohols to produce the fluorene-fused furan compounds. Broad substrate scope, regioselectivity, gram-scale synthesis, and benzylic functionalization of products are some of the highlights of this protocol.

Ca(II)-Mediated Regioselective One-pot Sequential Annulation of Acyclic compounds to Polycyclic Fluorenopyrans

Herein we report a facile synthesis of tetracyclic fluorenopyrans from simple acyclic reactants, propargyl alcohols and 3-methylpentane-2,4-dione under calcium catalysis. This one-pot, 3-component reaction proceeds through a sequential allene formation, F

Calcium-Catalyzed Intramolecular Hydroamination-Deacylation Reaction of in situ formed β-Amino Allenes

We have developed a simple, One-Pot, three-component reaction of tert-propargyl alcohols, primary amines and acyl ketones to synthesize fully substituted pyrroles and pyridine derivatives in good to excellent yields with large substrate diversity. An eco-friendly calcium catalyst catalyzes the reaction to form the key intermediate β-amino allene that undergoes subsequent Thorpe-Ingold effect assisted hydroamination and aromaticity driven deacylation reaction to yield fully substituted five and six-membered azacyclic compounds. (Figure presented.).

Synthesis of 2-(Isoquinolin-1-yl)prop-2-en-1-ones via Silver(I)-Catalyzed One-Pot Tandem Reaction of ortho-Alkynylbenzaldoximes with Propargylic Alcohols

The silver(I)-catalyzed reaction of ortho-alkynylbenzaldoximes with propargylic alcohols represents a new strategy for the divergent one-pot synthesis of 2-(isoquinolin-1-yl) prop-2-en-1-ones via tandem 6-endo-cyclization, 1,3-dipolar cycloaddition, and intramolecular dehydrative opening of the 2,3-dihydroisoxazole ring. This synthetic protocol tolerates a wide variety of ortho-alkynylbenzaldoximes and propargylic alcohols and affords the corresponding products in excellent yields.