1000894-83-6 Usage
Description
tert-butyl 3,3-dimethyl-5-oxopiperidine-1-carboxylate, also known as 3,3-Dimethyl-5-oxo-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester, is a chemical compound with the molecular formula C10H17NO3. It is a white crystalline solid and is soluble in organic solvents. tert-butyl 3,3-dimethyl-5-oxopiperidine-1-carboxylate is an important intermediate in the synthesis of various pharmaceuticals and bioactive molecules.
Uses
Used in Pharmaceutical Industry:
tert-butyl 3,3-dimethyl-5-oxopiperidine-1-carboxylate is used as a reactant in the synthesis of novel inhibitors of HDM2-p53 protein-protein interactions. HDM2 is a well-known oncogene that negatively regulates the tumor suppressor protein p53, leading to uncontrolled cell growth and tumor development. By inhibiting the interaction between HDM2 and p53, these novel inhibitors can potentially restore the normal function of p53, leading to the suppression of tumor growth and the induction of apoptosis in cancer cells.
In addition to its use in the synthesis of HDM2-p53 inhibitors, tert-butyl 3,3-dimethyl-5-oxopiperidine-1-carboxylate can also be used as a building block for the development of other bioactive molecules with potential therapeutic applications. Its unique structure and reactivity make it a valuable component in the design and synthesis of new drugs targeting various diseases and disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 1000894-83-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,0,8,9 and 4 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1000894-83:
(9*1)+(8*0)+(7*0)+(6*0)+(5*8)+(4*9)+(3*4)+(2*8)+(1*3)=116
116 % 10 = 6
So 1000894-83-6 is a valid CAS Registry Number.
1000894-83-6Relevant articles and documents
Core modification of substituted piperidines as Novel inhibitors of HDM2-p53 protein-protein interaction
Pan, Weidong,Lahue, Brian R.,Ma, Yao,Nair, Latha G.,Shipps Jr., Gerald W.,Wang, Yaolin,Doll, Ronald,Bogen, Stéphane L.
, p. 1983 - 1986 (2014/04/17)
The discovery of 3,3-disubstituted piperidine 1 as novel p53-HDM2 inhibitors prompted us to implement subsequent SAR follow up directed towards piperidine core modifications. Conformational restrictions and further functionalization of the piperidine core were investigated as a strategy to gain additional interactions with HDM2. Substitutions at positions 4, 5 and 6 of the piperidine ring were explored. Although some substitutions were tolerated, no significant improvement in potency was observed compared to 1. Incorporation of an allyl side chain at position 2 provided a drastic improvement in binding potency.
