1000974-56-0Relevant articles and documents
Promising bactericidal approach of dihydrazone analogues against bio-film forming Gram-negative bacteria and molecular mechanistic studies
Rakesh,Vivek,Manukumar,Shantharam,Bukhari,Qin, Hua-Li,Sridhara
, p. 5473 - 5483 (2018/04/30)
Gram-negative members of the ESCAPE family are more difficult to treat, due to the presence of an additional barrier in the form of a lipopolysaccharide layer and the efficiency of efflux pumps to pump out the drugs from the cytoplasm. The development of alternative therapeutic strategies to tackle ESCAPE Gram-negative members is of extreme necessity to provide a solution to the cause of life-threatening infections. The present investigations demonstrated that compounds 17, 20, 25 and 26 possessing the presence of electron donating (OH and OCH3) groups on the phenyl rings are highly potent; whereas compounds 9, 10, 15, 16, 18, 33 and 36 showed moderate activity against Gram-negative bacteria. An excellent dose-dependent antibacterial activity was established compared to that of the standard antibiotic ampicillin. Significant anti-biofilm properties were measured quantitatively, showing optical density (O.D) values of 0.51 ± 015, 0.63 ± 0.20, 0.38 ± 0.07 and 0.62 ± 0.11 at 492 nm and the leakage of cellular components by the compounds, such as 17, 20, 25 and 26, increased the O.D. of respective treated samples compared to the control. In addition, the implication of experimental results is discussed in the light of the lack of survivability of planktonic bacteria and biofilm destruction in vitro. These results revealed the great significance of the development of a new generation of synthetic materials with greater efficacy in anti-biofilm properties by targeting to lock the bio-film associated protein Bap in Gram-negative bacteria.
Synthesis and antibacterial activities of 13-bis[3-N-acetyl-2-aryl-1,3,4- oxadiazoline-5-yl]benzenes
Li, De-Jiang,Dan, Fei-Jun,Fu, He-Qing
, p. 101 - 105 (2008/09/20)
Dimethyl isophthalate (1) was reacted with 80% hydrazine hydrate in refluxing ethanol for 16 h to give isophthalic dihydrazide (2). Condensation of 2 with aromatic aldehydes afforded corresponding hydrazones 3a-3i. Cyclization of 3a-3i with acetic anhydride in refluxing for 4-5 h afforded 1,3-Bis[3-N-acetyl-2-aryl-1,3,4-oxadiazoline-5-yl]benzenes (4a-4i). The structures of 4a-4i were characterized by elementary analyses, IR, 1H NMR, and MS spectroscopy. The preliminary antibacterial tests showed that most of them were effective against S.aureus.
