1001070-33-2

Basic information

• Product Name: 1-BENZENESULFONYL-5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE
• Synonyms: 1-BENZENESULFONYL-5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE
• CAS NO: 1001070-33-2
• Molecular Formula: C₁₃H₉BrN₂O₂S
• Molecular Weight: 337.19176
• Mol File: 1001070-33-2.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-BENZENESULFONYL-5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZENESULFONYL-5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE(1001070-33-2)
• EPA Substance Registry System: 1-BENZENESULFONYL-5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE(1001070-33-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 1001070-33-2(Hazardous Substances Data)

Usage

General Description

1-BENZENESULFONYL-5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE is a chemical compound with a molecular formula C16H10BrN3O2S. It is a pyrrolopyridine derivative that contains a benzene sulfonyl group and a bromine atom. 1-BENZENESULFONYL-5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE is used as a building block in organic synthesis and pharmaceutical research. It has been studied for its potential use in the development of new drugs, particularly in the treatment of cancer and other diseases. Its unique structure and properties make it an important molecule in the field of medicinal chemistry and drug discovery.

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 
• 10592-27-5 7-azaindoline 
• 754214-54-5 5-bromo-1-(tert-butyl-dimethyl-silanyl)-1H-pyrrolo[2,3-b]pyridine 
• 271-63-6 7-Azaindole 

Downstream Products

• 1111638-01-7 5-bromo-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 1111638-61-9 5-(1-ethoxyvinyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 1147998-27-3 1-(phenylsulfonyl)-5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine 
• 1147998-19-3 5-(1-methyl-1H-pyrazol-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 1312018-04-4 5-allyl-1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine 
• 1312017-88-1 1-benzenesulfonyl-5-vinyl-1H-pyrrolo[2,3-b]pyridine 
• 1254568-11-0 1-benzenesulfonyl-5-(3-methoxy-prop-1-ynyl)-1H-pyrrolo[2,3-b]pyridine 
• 1312016-01-5 1-{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-ethane-1,2-diol 
• 1312016-04-8 {2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-methanol 
• 1312016-06-0 1-{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-ethanol 
• 1312016-11-7 3-{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-propane-1,2-diol 
• 1312016-67-3 2-{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-ethanol 
• 1312016-69-5 dimethylamino-acetic acid 2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-ylmethyl-ester 
• 1312016-70-8 {2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-acetonitrile 

Relevant articles and documents

Design, synthesis and biological evaluation of 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine derivatives as c-Met inhibitors

Five novel 1H-pyrrolo[2,3-b]pyridine or 1H-pyrazolo[3,4-b]pyridine derivatives, with a methylene, sulfur, sulfoxide or cyclopropyl group as a linker, were designed, synthesized and biologically evaluated against c-Met and ALK. The development of these methods of compound synthesis may provide an important reference for the construction of novel 7-azaindole and 7-azaindazole derivatives with a single atom linker. The enzyme assay and cell assay in vitro showed that compound 9 displayed strong c-Met kinase inhibition with IC50 of 22.8 nM, moderate ALK kinase inhibition, and strong cell inhibition with MKN-45 IC50 of 329 nM and EBC-1 IC50 of 479 nM. In order to find the better candidate compounds, compounds 8, 9 and 10 have been selected as tool compounds for further optimization.

AZAINDOLE DERIVATIVE AND USE THEREOF AS FGFR AND C-MET INHIBITOR

A series of pyrazolopymidine derivatives, and use thereof in the preparation of a medicament for treating disease associated with FGFR and c-Met. The pyrazolopymidine derivative is a compound represented by formula (I), a tautomer, or a pharmaceutically acceptable salt thereof.

Compound serving as Hippo signal channel inhibitor

The invention provides a compound represented by a formula I, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof. The compound disclosed by the invention has an inhibiting effecton a Hippo signal channel, and can be used for preparing a Hippo signal channel inhibitor. Meanwhile, cell proliferation can be promoted by inhibiting a Hippo signal channel, regeneration of damagedorgans is facilitated, particularly regeneration of damaged liver tissues can be promoted, and acute liver injury can be effectively repaired. Therefore, the compound provided by the invention can also be used for preparing medicines for treating various diseases related to the Hippo signal channel, such as medicines beneficial to regeneration of damaged organs, particularly medicines beneficial to regeneration of damaged liver tissues, and medicines for repairing acute liver injury. The compound can be used for medication research in the field of organ regeneration.