1001162-89-5 Usage
General Description
2-Borono-1H-indol-1-carboxylic acid 1-Methyl ester, also known as 2-Borono-L-tryptophan 1-Methyl ester, is a chemical compound derived from tryptophan, an essential amino acid. 2-Borono-1H-indol-1-carboxylic acid 1-Methyl ester contains a boronic acid group, which has been shown to have potential biological activities such as antitumor, antiviral, and antibacterial properties. It has been studied for its potential use in cancer therapy and as a fluorescent probe for detecting reactive oxygen species in living cells. Additionally, it has been used in the synthesis of novel anticancer agents and other biologically active compounds. Overall, 2-Borono-1H-indol-1-carboxylic acid 1-Methyl ester is a versatile compound with promising therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1001162-89-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,1,1,6 and 2 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1001162-89:
(9*1)+(8*0)+(7*0)+(6*1)+(5*1)+(4*6)+(3*2)+(2*8)+(1*9)=75
75 % 10 = 5
So 1001162-89-5 is a valid CAS Registry Number.
1001162-89-5Relevant articles and documents
A scalable process for the synthesis of the Bcl inhibitor obatoclax
Dairi, Kenza,Yao, Yuxing,Faley, Michael,Tripathy, Sasmita,Rioux, Elise,Billot, Xavier,Rabouin, Daniel,Gonzalez, Gerson,Lavallee, Jean-Francois,Attardo, Giorgio
, p. 1051 - 1054 (2007)
Recently we created the novel indolylprodigiosin derivative 2 (obatodax) and demonstrated its ability to antagonize multiple members of the B-cell lymphoma (Bd) family of antiapoptotic proteins. The compound has shown potent anticancer activity in several animal tumor models. Obatodax is now in Phase 1b and 2 clinical trials directed against multiple hematologic and solid tumor malignancies. To support its clinical development, a new scalable synthesis was required. Obatodax has been prepared using a three-step synthesis, starting from commercially available 4-methoxy-3-pyrrolin-2-one. The reaction sequence involves a haloformylation reaction followed by a Suzuki cross-coupling reaction with an indole-2-boronic add. The synthesis is completed by an acid-mediated condensation with 2,4-dimethyl-1H-pyrrole.
