1001192-35-3

Basic information

• Product Name: 5-[N-(3-fluorobenzyl)-N-methylaminocarbonyl]-3-(3-methylbenzyl)-6-hydroxy-1H-indazole
• CAS NO: 1001192-35-3
• Molecular Weight: 403.456
• Mol File: 1001192-35-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-[N-(3-fluorobenzyl)-N-methylaminocarbonyl]-3-(3-methylbenzyl)-6-hydroxy-1H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[N-(3-fluorobenzyl)-N-methylaminocarbonyl]-3-(3-methylbenzyl)-6-hydroxy-1H-indazole(1001192-35-3)
• EPA Substance Registry System: 5-[N-(3-fluorobenzyl)-N-methylaminocarbonyl]-3-(3-methylbenzyl)-6-hydroxy-1H-indazole(1001192-35-3)

Safety Data

• Hazardous Substances Data: 1001192-35-3(Hazardous Substances Data)

Upstream product

• 90389-84-7 1-(3-fluorophenyl)-N-methylmethanamine 
• 1384440-41-8 C₁₇H₁₆N₂O₃ 
• 1384440-42-9 C₁₈H₁₈N₂O₃ 
• 1001195-64-7 5-bromo-6-methoxy-3-(3-methylbenzyl)-1H-indazole 

Relevant articles and documents

Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90

Inhibitors of the Hsp90 molecular chaperone are showing considerable promise as potential molecular therapeutic agents for the treatment of cancer. Here we describe the identification of novel small molecular weight inhibitors of Hsp90 using a fragment based approach. Fragments were selected by docking, tested in a biochemical assay and the confirmed hits were crystallized. Information gained from X-ray structures of these fragments and other chemotypes was used to drive the fragment evolution process. Optimization of these high μM binders resulted in 3-benzylindazole derivatives with significantly improved affinity and anti-proliferative effects in different human cancer cell lines.