1001242-92-7

Basic information

• Product Name: 2-(4-morpholin-4-ylbenzyl)-1H-isoindole-1,3(2H)-dione
• Synonyms: 2-(4-morpholin-4-ylbenzyl)-1H-isoindole-1,3(2H)-dione
• CAS NO: 1001242-92-7
• Molecular Weight: 322.364
• Mol File: 1001242-92-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-morpholin-4-ylbenzyl)-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-morpholin-4-ylbenzyl)-1H-isoindole-1,3(2H)-dione(1001242-92-7)
• EPA Substance Registry System: 2-(4-morpholin-4-ylbenzyl)-1H-isoindole-1,3(2H)-dione(1001242-92-7)

Safety Data

• Hazardous Substances Data: 1001242-92-7(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 153171-22-3 2-(4-bromobenzyl)-1H-isoindole-1,3(2H)-dione 

Downstream Products

• 214759-74-7 1-(4-morpholin-4-ylphenyl)methanamine 

Relevant articles and documents

Potent inhibitors of tRNA-guanine transglycosylase, an enzyme linked to the pathogenicity of the Shigella bacterium: Charge-assisted hydrogen bonding

Improving inhibition: tRNA-Guanine transglycosylase (TGT) is a newly recognized target to reduce the pathogenicity of disease-causing Shigella bacteria. A potent family of inhibitors of this enzyme has been developed by structure-based design. Crystallographic data and pKa, analysis suggest that the aminoimidazole moiety of the central lin-benzoguanine scaffold is protonated and stabilization of the complexes results from charge-assisted hydrogen bonding. (Figure Presented).